Down syndrome vs Individuals without Down syndrome (healthy controls: siblings, schoolchildren or others): Dental caries
- Population
- Individuals of all ages
- Intervention
- Down syndrome
- Comparison
- Individuals without Down syndrome (healthy controls: siblings, schoolchildren or others)
- Outcome
- Dental caries
Individuals with Down syndrome had a lower prevalence of dental caries than those without (pooled OR 0.36, 95% CI 0.22 to 0.57; 2 studies; I2=0%); certainty of evidence not graded.
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Down syndrome (trisomy 21) vs Individuals without Down syndrome (healthy controls: siblings, schoolchildren or others) Dental caries (presence vs absence; all teeth, deciduous and permanent) · Individuals of any age (no age limit; ages 1 to 84 years across studies) · Individuals with and without Down syndrome in Portugal (reference centre, national database and closest-age siblings); cross-sectional studies Individuals with Down syndrome had a lower prevalence of dental caries than those without (pooled OR 0.36, 95% CI 0.22 to 0.57; 2 studies; I2=0%); certainty of evidence not graded. Association between Dental Caries and Down Syndrome: A Systematic Review and Meta-Analysis. (2015) All outcomes | OR 0.36 [0.22, 0.57] | 2 studies · 314 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Association between Dental Caries and Down Syndrome: A Systematic Review and Meta-Analysis. 2015 All outcomes | March 2013; updated September 2014 | 15 | Not applicable |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Down syndrome vs Healthy controls · Children with Down syndrome in Dubai · 1 review
Studies behind the findings
The primary studies the full-text reviews tie to this outcome. Reviews with headline outcomes only do not list them here.
- Comparative study between dental caries prevalence of Down syndrome children and their siblings · 2012 · included by 1 of these review
- Areias et al., 2011 · included by 1 of these review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.