Non-Cochrane · aetiology · PM26086498
Association between Dental Caries and Down Syndrome: A Systematic Review and Meta-Analysis.
Deps Tahyna Duda, Angelo Gabriela Lopes, Martins Carolina Castro, et al. · PloS one · 2015 · PubMed · doi:10.1371/journal.pone.0127484
Full textEvery question was extracted from the full text, figures and supplements by two independent LLM extractors, disagreements adjudicated. Rows cite where in the review the value comes from.
Questions
2
current version
GRADE rated
0
No studies
0
Included studies
15
linked below
No studies 0 · 0%Ungraded 2 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Individuals of any age (no age limit) | Individuals with and without Down syndrome across 13 cross-sectional studies (ages 1 to 84 years; sample sizes 47 to 336); 8 studies in meta-analysis |
| Intervention | Down syndrome (trisomy 21) as exposure to risk factor | Down syndrome (trisomy 21) |
| Comparison | Individuals without Down syndrome (healthy control group) | Individuals without Down syndrome (siblings, schoolchildren or other controls) |
| Outcomes | Dental caries (prevalence, incidence or experience), measured by DMFT/DMFS/dmft/dmfs indices or presence/absence of caries | Caries presence/absence (all teeth): OR 0.36 (95% CI 0.22 to 0.57; 2 studies; I2=0%). Mean DMFT (permanent teeth): SMD -0.18 (95% CI -0.35 to -0.02; 6 studies; I2=20.32%) |
| Study designs | Observational epidemiological studies (cross-sectional, case-control, cohort) with a comparison group; excluded studies without a control group, case reports/series, literature reviews, studies without statistical analysis, and outcomes other than dental caries | 13 cross-sectional studies in the systematic review; 8 in the meta-analysis; Newcastle-Ottawa quality 3 to 7 of 8 (generally high risk of bias) |
| Timing | Not specified | Not specified (cross-sectional) |
Search date: March 2013; updated September 2014. Databases: Medline via PubMed, Web of Science, Cochrane Library, Brazilian Library of Dentistry (BBO), and LILACS (Latin American and Caribbean System of Health Sciences) via Bireme; plus manual search of reference lists
Questions and results
Down syndrome (trisomy 21) vs Individuals without Down syndrome (healthy controls: siblings, schoolchildren or others)
Population: Individuals of any age (no age limit; ages 1 to 84 years across studies)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Dental caries experience (mean DMFT; permanent teeth) Individuals with Down syndrome had a lower mean DMFT in permanent teeth than controls (pooled SMD -0.18, 95% CI -0.35 to -0.02; 6 studies; I2=20%); certainty of evidence not graded. Source: Results (Data Synthesis); Abstract; S3 Fig · same question in other reviews | SMD -0.18 [-0.35, -0.02] | 6 studies · 718 participants | Ungraded |
Dental caries (presence vs absence; all teeth, deciduous and permanent) Individuals with Down syndrome had a lower prevalence of dental caries than those without (pooled OR 0.36, 95% CI 0.22 to 0.57; 2 studies; I2=0%); certainty of evidence not graded. Source: Results (Data Synthesis); Abstract; S2 Fig · same question in other reviews | OR 0.36 [0.22, 0.57] | 2 studies · 314 participants | Ungraded |
Included primary studies 15
Open as a trial list| Study | Also included by | Outcomes it informs here | Trial PICO | Results |
|---|---|---|---|---|
| Al Habashneh 2012 matched by author and year (probable) | 1 other review | Dental caries experience (mean DMFT; permanent teeth) | not extracted yet | not extracted yet |
| Al Habashneh et al., 2012 Oral health status and reasons for not attending dental care among 12‐ to 16‐year‐old children with Down syndrome in special needs centres… DOI:10.1111/j.1601-5037.2012.00545.x | 1 other review | Dental caries experience (mean DMFT; permanent teeth) | not extracted yet | not extracted yet |
| Cogulu et al., 2006 matched by author and year (probable) | 1 other review | not stated | not extracted yet | not extracted yet |
| Mathias et al., 2011 matched by author and year (probable) | 1 other review | Dental caries experience (mean DMFT; permanent teeth) | not extracted yet | not extracted yet |
| Subramaniam 2014 matched by author and year (probable) | 1 other review | Dental caries experience (mean DMFT; permanent teeth) | not extracted yet | not extracted yet |
| Subramaniam et al., 2014 Assessment of salivary total antioxidant levels and oral health status in children with Down syndrome DOI:10.1111/scd.12054 | 1 other review | Dental caries experience (mean DMFT; permanent teeth) | not extracted yet | not extracted yet |
| Areias et al., 2011 matched by author and year (probable) | this review only | Dental caries (presence vs absence; all teeth, deciduous and permanent) | not extracted yet | not extracted yet |
| Areias et al., 2012 matched by author and year (probable) | this review only | Dental caries experience (mean DMFT; permanent teeth) | not extracted yet | not extracted yet |
| Cheng et al., 2007 matched by author and year (probable) | this review only | Dental caries experience (mean DMFT; permanent teeth) | not extracted yet | not extracted yet |
| Khocht 2010 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Khocht et al., 2010 Periodontal health in Down syndrome: Contributions of mental disability, personal, and professional dental care DOI:10.1111/j.1754-4505.2010.00134.x | this review only | not stated | not extracted yet | not extracted yet |
| Macho et al., 2013 Comparative study between dental caries prevalence of Down syndrome children and their siblings DOI:10.1111/j.1754-4505.2012.00297.x | this review only | Dental caries (presence vs absence; all teeth, deciduous and permanent) | not extracted yet | not extracted yet |
| Oredugba, 2007 matched by author and year (probable) | this review only | Dental caries experience (mean DMFT; permanent teeth) | not extracted yet | not extracted yet |
| Orner, 1975 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Yarat et al., 1999 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match).
| Review | Shared studies | Jaccard |
|---|---|---|
| Dental caries experience, care index and restorative index in children with learning disabilities and children without learning… (2019) | 6 | 0.11 |