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Evidence found and GRADE certainty

1,411 questions · 1,474 findings · 170 reviews

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No studies found 336 · 22.8%GRADE not reported 97 · 6.6%Very low 419 · 28.4%Low 395 · 26.8%Moderate 188 · 12.8%High 39 · 2.6%

Trazodone vs placebo

Change in feeling of dryness · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

The review found no eligible studies for this question.

1 finding from 1 review

Benzodiazepines (systemic clonazepam) vs placebo

Change in taste · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether benzodiazepines (systemic clonazepam) changes change in taste compared with placebo (very low certainty).

1 finding from 1 review

Dietary supplements (alpha lipoic acid +/- vitamins) vs placebo

Relief of burning/discomfort (symptom relief; pain intensity) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether dietary supplements (alpha lipoic acid +/- vitamins) changes relief of burning/discomfort (symptom relief; pain intensity) compared with placebo (very low certainty).

1 finding from 1 review

Anticonvulsants (gabapentin + alpha lipoic acid) vs placebo

Relief of burning/discomfort (symptom relief; pain intensity) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
1 finding from 1 review
  • Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes
    short-term (up to 3 months) · gabapentin with adjunctive ALA
    SoF2 subgroup. Gabapentin + adjunctive ALA vs placebo forms one of two subgroups of the anticonvulsant symptom-relief estimate (RR 4.00, 2.09 to 7.67); no between-subgroup difference vs gabapentin alone; 100…
    1 study · 40 participants
    Very low

Low‐level laser therapy vs placebo

Change in taste · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

The review found no eligible studies for this question.

1 finding from 1 review

Antidepressants (trazodone 200 mg/day) vs placebo

QoL · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
1 finding from 1 review
  • Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes
    short-term (up to 3 months)
    SoF1. Change in QoL short-term (mean Beck Depression Inventory, 0-63, lower better): this single study narratively reported that both intervention and placebo participants were less depressed at trial completion, but…
    1 study · 37 participants
    Very low

Dietary supplements (alpha lipoic acid +/- adjunctive ingredients) vs placebo

Adverse events: worsening of hypertension · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether dietary supplements (alpha lipoic acid +/- adjunctive ingredients) changes adverse effects: increase in blood pressure compared with placebo (very low certainty).

1 finding from 1 review

Transbond Plus self etching primer (3M Unitek) vs Clearfil Protect Bond self etching primer (Kuraray Medical)

Bond failure rate · Children and adults with fixed orthodontic brackets bonded to incisors, canines and premolars
1 finding from 1 review
  • Enamel etching for bonding fixed orthodontic braces 2013 · Cochrane All outcomes
    Self etching primers versus self etching primers: Two split-mouth studies compared two different SEPs (Noble 2006; Paschos 2009). The failure rates were reported at tooth level rather than at participant level. We…
    1 study
    GRADE not reported

Transbond Plus self etching primer (3M Unitek) vs Clearfil Protect Bond self etching primer (Kuraray Medical)

Decay (decalcification) associated with or around the etching field · Children and adults with fixed orthodontic brackets bonded to incisors, canines and premolars
1 finding from 1 review
  • Enamel etching for bonding fixed orthodontic braces 2013 · Cochrane All outcomes
    Decalcification outcomes in Paschos 2009 were reported at tooth level rather than at participant level; the evidence was insufficient to conclude whether or not there is a difference in decalcification between the…
    1 study
    GRADE not reported

Surgery vs any Medical Therapy

NON ‐ Healing (persistence or recurrence) · people with anal fissures

Any Surgery leads to lower NON ‐ Healing (persistence or recurrence) compared with any Medical Therapy (high certainty).

1 finding from 1 review