The review found no eligible studies for this question.
It is very uncertain whether regimens containing quinolone changes adverse events: any antibiotic‐related adverse event leading to… compared with regimens containing cephalosporins (very low certainty).
Regimens containing nitroimidazole showed no clear difference in adverse events: any antibiotic‐related adverse event leading to… compared with no nitroimidazole (low certainty).
It is very uncertain whether regimens containing clindamycin plus aminoglycoside changes adverse events: any antibiotic‐related adverse event leading to… compared with regimens containing quinolone (very low certainty).
It is very uncertain whether regimens containing clindamycin plus aminoglycoside changes adverse events: any antibiotic‐related adverse event leading to… compared with regimens containing cephalosporin (very low certainty).
Regimens containing macrolides (azithromycin) showed no clear difference in adverse events: any antibiotic‐related adverse event leading to… compared with regimens containing tetracycline (doxycycline) (low certainty).
Oral azithromycin led to lower antibiotic resistance Proportion of samples showing evidence of… compared with control; GRADE not reported.
The review found no eligible studies for this question.
Procalcitonin algorithm probably leads to lower antibiotic‐related side effects compared with standard care (moderate certainty).
It is very uncertain whether the intervention changes number of participants who experienced any adverse effects related… (very low certainty).
Written information for patients (or parents of child patients) probably leads to lower antibiotics used by patients compared with usual care (moderate certainty).
Written information for patients (or parents of child patients) may leads to lower antibiotics prescribed by clinicians compared with usual care (low certainty).
Written information for patients (or parents of child patients) plus… may leads to higher antibiotics prescribed by clinicians compared with prescribing feedback alone (low certainty).
It is very uncertain whether monotherapy changes clinical failure—same beta lactam Antibiotic modifications compared with combination therapy compared (very low certainty).
It is very uncertain whether monotherapy changes clinical failure—different beta lactam Antibiotic modifications compared with combination therapy compared (very low certainty).
It is very uncertain whether any antibiotic regimen plus N‐acetylcysteine changes eradication rate compared with the same regimen without N‐acetylcysteine (with or without placebo) (very low certainty).
It is very uncertain whether any antibiotic regimen plus N‐acetylcysteine changes gastrointestinal adverse events compared with the same regimen without N‐acetylcysteine (with or without placebo) (very low certainty).
It is very uncertain whether any antibiotic regimen plus N‐acetylcysteine changes allergic adverse events compared with the same regimen without N‐acetylcysteine (with or without placebo) (very low certainty).