Cochrane · systematic review · CD012357
N‐acetylcysteine as an adjuvant therapy for Helicobacter pylori eradication
Fontes, LES, Martimbianco, ALC, Zanin, C, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
GutAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 75%Low 1 · 25%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Any antibiotic regimen plus N‐acetylcysteine compared to the same regimen without N‐acetylcysteine (with or without placebo) for Helicobacter pylori infection
Population: people withH pylori infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Eradication rate Any antibiotic regimen plus N‐acetylcysteine vs the same regimen without N‐acetylcysteine (with or without placebo) | RR 0.74 [0.51, 1.08] | 8 studies · 559 participants | Very low Downgraded: risk of bias |
Gastrointestinal adverse events Any antibiotic regimen plus N‐acetylcysteine vs the same regimen without N‐acetylcysteine (with or without placebo) | RR 1.25 [0.85, 1.85] | 5 studies · 336 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Allergic adverse events Any antibiotic regimen plus N‐acetylcysteine vs the same regimen without N‐acetylcysteine (with or without placebo) | RR 2.98 [0.32, 27.74] | 5 studies · 336 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Toxic adverse events Any antibiotic regimen plus N‐acetylcysteine vs the same regimen without N‐acetylcysteine (with or without placebo) | no estimate extracted | 5 studies · 336 participants | Low Downgraded: risk of bias, imprecision, inconsistency |