Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,072 questions · 4,237 findings · 447 reviews · Headline outcomes only

No studies found 946 · 22.3%GRADE not reported 257 · 6.1%Very low 1,121 · 26.5%Low 1,207 · 28.5%Moderate 568 · 13.4%High 138 · 3.3%

Fish oil lipid emulsion (LE) vs non‐fish oil LE

ROP ≥ stage 3 or requiring surgery – all fish oil LE vs non‐fish oil LE · Parenterally fed preterm infants

It is very uncertain whether fish oil lipid emulsion (LE) changes ROP ≥ stage 3 or requiring surgery – all fish oil LE vs non‐fish oil… compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Perioperative alcohol cessation intervention vs treatment

Postoperative complications after perioperative intervention (e.g. wound‐related complications, secondary surgery, cardiopulmonary complications, admission to intensive care) defined by need for treatment · adult surgical patients consuming 3 or more units of alcohol per day

Perioperative alcohol cessation intervention probably leads to lower postoperative complications after perioperative intervention (e.g.… compared with treatment (moderate certainty).

1 finding from 1 review

Prosthetic mesh placement vs usual care

Subgroup analysis:Incidence of parastomal hernia (open surgery) ( · individuals having a stoma formation

Prosthetic mesh placement probably leads to lower subgroup analysis:Incidence of parastomal hernia (open surgery) ( compared with standard treatment (moderate certainty).

1 finding from 1 review

NPWT vs dressings

Number of wounds closed or covered with surgery · treating foot wounds in people with diabetes mellitus

NPWT showed no clear difference in number of wounds closed or covered with surgery compared with dressings (low certainty).

2 findings from 1 review

Low‐pressure vs high‐pressure NPWT

Number of wounds closed or covered with surgery · treating foot wounds in people with diabetes mellitus

It is very uncertain whether low‐pressure changes number of wounds closed or covered with surgery compared with high‐pressure NPWT (very low certainty).

1 finding from 1 review

Laparoscopic retroperitoneal adrenalectomy vs laparoscopic transperitoneal adrenalectomy

Early morbidity (any complication during the first 30 to 60 days following surgery)

It is very uncertain whether laparoscopic retroperitoneal adrenalectomy changes early morbidity (any complication during the first 30 to 60 days… compared with laparoscopic transperitoneal adrenalectomy (very low certainty).

1 finding from 1 review

Laparoscopic retroperitoneal adrenalectomy vs laparoscopic transperitoneal adrenalectomy

Late morbidity (any complication following surgery at latest available

It is very uncertain whether laparoscopic retroperitoneal adrenalectomy changes late morbidity (any complication following surgery at latest available compared with laparoscopic transperitoneal adrenalectomy (very low certainty).

1 finding from 1 review

Probiotics administered exclusively after birth in mothers of preterm infants vs placebo or no intervention

NEC‐related surgery during study period · preterm infants

Probiotics administered exclusively after birth in mothers of… showed no clear difference in surgery for NEC compared with maternal placebo or no intervention (low certainty).

1 finding from 1 review

Repeated lumbar or ventricular punctures vs conservative treatment

Infection of CSF presurgery · preterm infants less than three months of age with either: a) IVH demonstrated by ultrasound or computed tomography (CT) scan; or b)…

Repeated lumbar or ventricular punctures showed no clear difference in infection of CSF presurgery compared with conservative treatment (low certainty).

1 finding from 1 review

Ahmed implant vs Baerveldt implant

Proportion needing additional glaucoma surgery at 1‐year · People with glaucoma

Ahmed implant probably leads to higher proportion needing additional glaucoma surgery at 1‐year compared with baerveldt implant (moderate certainty).

1 finding from 1 review

Ahmed implant vs Molteno implant

Proportion needing additional glaucoma surgery at 1‐year · People with glaucoma

The review found no eligible studies for this question.

1 finding from 1 review