Cochrane · systematic review · CD012522
Negative pressure wound therapy for open traumatic wounds
Iheozor‐Ejiofor, Z, Newton, K, Dumville, JC, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
WoundsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
20
current version
GRADE rated
7
No studies
12
Included studies
NR
No studies 12 · 60%Ungraded 1 · 5%Very low 4 · 20%Low 2 · 10%Moderate 1 · 5%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
NPWT 125 mmHg compared with standard care in open fracture wounds
Population: open fracture wounds
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete wound healing NPWT 125 mmHg vs standard care | RR 1.01 [0.81, 1.27] | 1 study · 460 participants | Moderate Downgraded: imprecision |
Wound infection NPWT 125 mmHg vs standard care | RR 0.48 [0.2, 1.13] | 4 studies · 596 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Adverse events NPWT 125 mmHg vs standard care | no estimate extracted | 1 study · 460 participants | Ungraded |
Time to closure or coverage surgery (days) NPWT 125 mmHg vs standard care | no estimate extracted | 2 studies · 151 participants | Very low Downgraded: risk of bias, imprecision |
Pain NPWT 125 mmHg vs standard care | no estimate extracted | NR | No studies |
NPWT 125 mmHg compared with standard care in other open traumatic wounds
Population: other open traumatic wounds
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete wound healing NPWT 125 mmHg vs standard care | no estimate extracted | NR | No studies |
Wound infection NPWT 125 mmHg vs standard care | RR 0.61 [0.31, 1.18] | 2 studies · 509 participants | Low Downgraded: risk of bias, imprecision |
Adverse events NPWT 125 mmHg vs standard care | no estimate extracted | NR | No studies |
Time to closure or coverage surgery NPWT 125 mmHg vs standard care | no estimate extracted | NR | No studies |
Pain NRS from 0 (no pain) to 10 (worst possible pain) NPWT 125 mmHg vs standard care | no estimate extracted | 1 study · 51 participants | Low Downgraded: risk of bias, imprecision |
NPWT 75 mmHg compared with standard care in other open traumatic wounds
Population: other open traumatic wounds
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete wound healing NPWT 75 mmHg vs standard care | no estimate extracted | NR | No studies |
Wound infection NPWT 75 mmHg vs standard care | RR 0.44 [0.17, 1.1] | 1 study · 463 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events NPWT 75 mmHg vs standard care | no estimate extracted | NR | No studies |
Time to closure or coverage surgery NPWT 75 mmHg vs standard care | no estimate extracted | NR | No studies |
Pain NPWT 75 mmHg vs standard care | no estimate extracted | NR | No studies |
NPWT 125 mmHg compared with NPWT 75 mmHg in other open traumatic wounds
Population: other open traumatic wounds
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete wound healing NPWT 125 mmHg vs NPWT 75 mmHg | no estimate extracted | NR | No studies |
Wound infection NPWT 125 mmHg vs NPWT 75 mmHg | RR 1.04 [0.31, 3.51] | 1 study · 251 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events NPWT 125 mmHg vs NPWT 75 mmHg | no estimate extracted | NR | No studies |
Time to closure or coverage surgery NPWT 125 mmHg vs NPWT 75 mmHg | no estimate extracted | NR | No studies |
Pain NPWT 125 mmHg vs NPWT 75 mmHg | no estimate extracted | NR | No studies |