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Evidence found and GRADE certainty

828 questions · 1,477 findings · 103 reviews

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No studies found 5 · 0.3%GRADE not reported 1,402 · 94.9%Very low 38 · 2.6%Low 20 · 1.4%Moderate 11 · 0.7%High 1 · 0.1%

Illicit drug use vs People who do not use drugs

Periodontal disease · People who use drugs (PWUD): methamphetamine, heroin, opiate, cannabis and cocaine users

Illicit drug use was not significantly associated with periodontal disease (pooled OR 1.44, 95% CI 0.80-2.60; 5 studies; substantial heterogeneity I2=85%; ungraded).

1 finding from 1 review

Learning disability (CLD) vs No learning disability (CNLD)

Care index (CI), permanent teeth · Children aged 1-18 years

The care index (met dental care need) for permanent teeth could not be meta-analyzed because no study reported variance; it was lower or equal in children with learning disabilities in 5 of 8 studies (certainty not graded).

1 finding from 1 review

Learning disability (CLD) vs No learning disability (CNLD)

Restorative index (RI), permanent teeth · Children aged 1-18 years

The restorative index for permanent teeth could not be meta-analyzed (no variance data); it was lower or equal in children with learning disabilities in 4 of 9 studies, and the pattern suggested more extraction- than restoration-based care in CLD (certainty not graded).

1 finding from 1 review

Antimicrobial photodynamic therapy (PDT) vs No photodynamic therapy (untreated negative control)

Microbial reduction (viable count, log CFU/mL) · Cariogenic bacteria (mainly Streptococcus mutans reference strains) and oral biofilms in vitro

In in vitro studies, photodynamic therapy significantly reduced cariogenic microbial counts versus untreated control (SMD -2.64, 95% CI -4.50 to -0.79; 2 studies; I2=0%); certainty was not graded.

1 finding from 1 review

Women who experienced preterm birth vs Women who did not experience preterm birth (term)

Decayed, missing, filled surfaces (DMFS) · pregnant women

Women who experienced preterm birth did not have a significantly different DMFS than those who did not (mean difference -0.15, 95% CI -3.40 to 3.09; 3 studies; I2=89%); certainty of evidence not graded.

1 finding from 1 review
  • Dental caries and preterm birth: a systematic review and meta-analysis. 2018 All outcomes
    Pregnant women assessed around delivery in observational studies across multiple countries (Mexico, Malawi, India, France, Jordan, Finland, Tanzania); mostly retrospective cohort and case-control designs
    MD -0.15 [-3.40, 3.09]
    3 studies · 2594 participants
    GRADE not reported

Women who experienced preterm birth vs Women who did not experience preterm birth (term)

Dental caries · pregnant women

Women who experienced preterm birth did not have significantly higher DMFT than those who did not (mean difference 1.56, 95% CI -0.28 to 3.41; 5 studies; I2=92%); certainty of evidence not graded.

1 finding from 1 review
  • Dental caries and preterm birth: a systematic review and meta-analysis. 2018 All outcomes
    Pregnant women assessed around delivery in observational studies across multiple countries (Mexico, Malawi, India, France, Jordan, Finland, Tanzania); mostly retrospective cohort and case-control designs
    MD 1.56 [-0.28, 3.41]
    5 studies · 2963 participants
    GRADE not reported