Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

884 questions · 892 findings · 68 reviews · Anaesthesia

No studies found 118 · 13.2%GRADE not reported 156 · 17.5%Very low 187 · 21%Low 270 · 30.3%Moderate 119 · 13.3%High 42 · 4.7%

Low tidal volume vs high tidal volume

Barotrauma (pneumothorax) · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…

It is very uncertain whether low tidal volume changes barotrauma: pneumothorax compared with high tidal volume (very low certainty).

1 finding from 1 review

Buffered vs non‐buffered crystalloid intravenous fluid

Mortality (in‐hospital death and 30‐day mortality) · adults receiving intravenous fluids whilst undergoing any form of surgery

Buffered showed no clear difference in mortality (in‐hospital death and 30‐day mortality) compared with non‐buffered crystalloid intravenous fluid (low certainty).

1 finding from 1 review

Buffered vs non‐buffered crystalloid intravenous fluid

Organ system failure ‐ renal insufficiency requiring support · adults receiving intravenous fluids whilst undergoing any form of surgery

Buffered showed no clear difference in organ system failure ‐ renal insufficiency requiring support compared with non‐buffered crystalloid intravenous fluid (low certainty).

1 finding from 1 review

Intravenous dexamethasone vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · participants undergoing surgery with peripheral nerve block
3 findings from 1 review

Perineural dexamethasone vs placebo

Incidence of serious adverse events (we used the NIH definition of adverse events. A serious event includes death, a life‐threatening event that requires hospitalization or prolonged hospitalization, disability or congenital anomaly) · participants undergoing surgery with peripheral nerve block
1 finding from 1 review

Perineural dexamethasone vs placebo

Postoperative pain intensity in the immediate postobturation period (up to 72 hours), continuous (VAS) · participants undergoing surgery with peripheral nerve block
3 findings from 1 review

Intravenous dexamethasone vs placebo

Incidence of serious adverse events (we used the NIH definition of adverse events. A serious event includes death, a life‐threatening event that requires hospitalization or prolonged hospitalization, disability or congenital anomaly) · participants undergoing surgery with peripheral nerve block

The review found no eligible studies for this question.

1 finding from 1 review