Cochrane · systematic review · CD005576
Hypertonic salt solution for peri‐operative fluid management
Shrum, B, Church, B, McArthur, E, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
AnaesthesiaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 28.6%Low 1 · 14.3%Moderate 3 · 42.9%High 1 · 14.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Hypertonic salt compared to isotonic salt solution for peri‐operative resuscitation
Population: any people undergoing surgery with fluid resuscitation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Hypertonic salt vs isotonic salt solution | no estimate extracted | 18 studies · 1087 participants | Very low Downgraded: imprecision, indirectness, publication bias |
Serious adverse events Hypertonic salt vs isotonic salt solution | no estimate extracted | 18 studies · 1087 participants | Very low Downgraded: imprecision, indirectness, publication bias |
Fluid balance (L) Hypertonic salt vs isotonic salt solution | no estimate extracted | 8 studies · 737 participants | Low Downgraded: risk of bias, imprecision |
Total volume of crystalloid administered (L) Hypertonic salt vs isotonic salt solution | no estimate extracted | 13 studies · 871 participants | Moderate Downgraded: imprecision |
Peak serum sodium Hypertonic salt vs isotonic salt solution | no estimate extracted | 16 studies · 780 participants | Moderate Downgraded: imprecision |
Final serum sodium Hypertonic salt vs isotonic salt solution | no estimate extracted | 12 studies · 640 participants | Moderate Downgraded: imprecision |
Maximum intraoperative cardiac index Hypertonic salt vs isotonic salt solution | no estimate extracted | 6 studies · 418 participants | High |