Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,679 questions · 1,720 findings · 335 reviews · Headline outcomes only

No studies found 192 · 11.2%GRADE not reported 75 · 4.4%Very low 526 · 30.6%Low 504 · 29.3%Moderate 305 · 17.7%High 118 · 6.9%

SUPPORTIVE THERAPY vs usual care

Leaving the study early · patients with schizophrenia

It is very uncertain whether SUPPORTIVE THERAPY changes leaving the study early compared with STANDARD CARE (very low certainty).

1 finding from 1 review

Aminophylline vs placebo

Early administration of aminophylline: survival to hospital admission · participants with bradyasystolic cardiac arrest in adults

Aminophylline showed no clear difference in early administration of aminophylline: survival to hospital admission compared with placebo (low certainty).

1 finding from 1 review

Aminophylline vs placebo

Return of spontaneous circulation · participants with bradyasystolic cardiac arrest in adults

Aminophylline showed no clear difference in early administration of aminophylline: return of spontaneous… compared with placebo (low certainty).

1 finding from 1 review

Combination chemotherapy vs single‐agent chemotherapy

Toxicity ‐ early adverse events G3/4 · people with resectable stage II and III rectal cancer undergoing preoperative chemoradiation followed by surgery

Combination chemotherapy probably leads to higher toxicity ‐ early adverse events G3/4 compared with single‐agent chemotherapy (moderate certainty).

1 finding from 1 review

Standardised formal neonatal resuscitation training (SFNRT) programme vs basic resuscitation training

Early neonatal mortality · Neonates delivered stratified by healthcare professionals involved in attending deliveries

Standardised formal neonatal resuscitation training (SFNRT) programme showed no clear difference in early neonatal mortality (mortality in the first 7 days of life) compared with basic resuscitation training (moderate certainty).

1 finding from 1 review

Standardised formal neonatal resuscitation training (SFNRT) programme vs basic resuscitation training

Early neonatal mortality ‐ traditional birth attendants · Neonates delivered stratified by healthcare professionals involved in attending deliveries

Standardised formal neonatal resuscitation training (SFNRT) programme probably leads to lower early neonatal mortality ‐ traditional birth attendants compared with basic resuscitation training (moderate certainty).

1 finding from 1 review

Standardised formal neonatal resuscitation training (SFNRT) programme vs basic resuscitation training

Early neonatal mortality ‐ nurse/midwife · Neonates delivered stratified by healthcare professionals involved in attending deliveries

Standardised formal neonatal resuscitation training (SFNRT) programme showed no clear difference in early neonatal mortality ‐ nurse/midwife compared with basic resuscitation training (moderate certainty).

1 finding from 1 review

Standardised formal neonatal resuscitation training (SFNRT) programme vs basic resuscitation training

Early neonatal mortality ‐ physician · Neonates delivered stratified by healthcare professionals involved in attending deliveries

Standardised formal neonatal resuscitation training (SFNRT) programme showed no clear difference in early neonatal mortality ‐ physician compared with basic resuscitation training (low certainty).

1 finding from 1 review

Standardised formal neonatal resuscitation training (SFNRT) programme vs basic resuscitation training

Early neonatal mortality ‐ family/unattended · Neonates delivered stratified by healthcare professionals involved in attending deliveries

Standardised formal neonatal resuscitation training (SFNRT) programme probably leads to lower early neonatal mortality ‐ family/unattended compared with basic resuscitation training (moderate certainty).

1 finding from 1 review

HALOPERIDOL vs first‐generation antipsychotics

Behaviour: Leaving the study early (short‐term) · patients with schizophrenia

Haloperidol showed no clear difference in leaving the study early due to any reason as a measure of overall… compared with first‐generation antipsychotics (low certainty).

1 finding from 1 review

HALOPERIDOL vs first‐generation antipsychotics

Leaving the study early ‐ short term ‐ due to lack of efficacy · patients with schizophrenia

It is very uncertain whether haloperidol changes leaving the study early due to inefficacy of treatment as a measure… compared with first‐generation antipsychotics (very low certainty).

1 finding from 1 review

HALOPERIDOL vs first‐generation antipsychotics

Leaving the study early ‐ due to adverse effects (short term) · patients with schizophrenia

It is very uncertain whether haloperidol changes leaving the study early due to adverse events as a measure of… compared with first‐generation antipsychotics (very low certainty).

1 finding from 1 review

HALOPERIDOL vs first‐generation antipsychotics

Leaving the study early ‐ medium term ‐ any reason · patients with schizophrenia

It is very uncertain whether haloperidol changes leaving the study early due to any reason as a measure of overall… compared with first‐generation antipsychotics (very low certainty).

1 finding from 1 review