Cochrane · systematic review · CD006081
Transcranial magnetic stimulation (TMS) for schizophrenia
Dougall, N, Maayan, N, Soares‐Weiser, K, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
28
current version
GRADE rated
17
No studies
10
Included studies
NR
No studies 10 · 35.7%Ungraded 1 · 3.6%Very low 4 · 14.3%Low 13 · 46.4%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
TEMPOROPARIETAL TMS compared to SHAM TMS for schizophrenia
Population: people with schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical improvement in global state CGI TEMPOROPARIETAL TMS vs SHAM TMS | RR 7 [0.38, 128.33] | 1 study · 46 participants | Very low Downgraded: risk of bias, imprecision |
Global state score CGI TEMPOROPARIETAL TMS vs SHAM TMS | no estimate extracted | 7 studies · 224 participants | Low Downgraded: risk of bias, imprecision |
Mental state PANSS TEMPOROPARIETAL TMS vs SHAM TMS | no estimate extracted | 5 studies · 127 participants | Low Downgraded: risk of bias, imprecision |
Cognitive state Various measures TEMPOROPARIETAL TMS vs SHAM TMS | no estimate extracted | 3 studies · 82 participants | Low Downgraded: imprecision |
Adverse effects: general or specific TEMPOROPARIETAL TMS vs SHAM TMS | no estimate extracted | 11 studies · 442 participants | Low Downgraded: risk of bias, imprecision |
Adverse effects: Leaving the study early TEMPOROPARIETAL TMS vs SHAM TMS | RR 0.78 [0.46, 1.32] | 8 studies · 320 participants | Low Downgraded: risk of bias, imprecision |
Satisfaction with care ‐ not reported TEMPOROPARIETAL TMS vs SHAM TMS | no estimate extracted | NR | No studies |
TEMPOROPARIETAL TMS compared to STANDARD TREATMENT for schizophrenia
Population: people with schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical improvement in global state CGI TEMPOROPARIETAL TMS vs STANDARD TREATMENT | RR 1.19 [0.91, 1.57] | 1 study · 100 participants | Low Downgraded: risk of bias, imprecision |
Global state score ‐ not reported TEMPOROPARIETAL TMS vs STANDARD TREATMENT | no estimate extracted | NR | No studies |
Mental state ‐ not reported TEMPOROPARIETAL TMS vs STANDARD TREATMENT | no estimate extracted | NR | No studies |
Cognitive state ‐ not reported TEMPOROPARIETAL TMS vs STANDARD TREATMENT | no estimate extracted | NR | No studies |
Adverse effects: general or specific ‐ not reported TEMPOROPARIETAL TMS vs STANDARD TREATMENT | no estimate extracted | NR | No studies |
Adverse effects: Leaving the study early TEMPOROPARIETAL TMS vs STANDARD TREATMENT | RR 0.33 [0.08, 1.46] | 2 studies · 140 participants | Very low Downgraded: risk of bias, imprecision |
Satisfaction with care ‐ not reported TEMPOROPARIETAL TMS vs STANDARD TREATMENT | no estimate extracted | NR | No studies |
PREFRONTAL TMS compared to SHAM TMS for schizophrenia
Population: people with schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical improvement in global state ‐ not reported PREFRONTAL TMS vs SHAM TMS | no estimate extracted | NR | No studies |
Global state score Various scales PREFRONTAL TMS vs SHAM TMS | no estimate extracted | 3 studies · 85 participants | Ungraded |
Mental state PANSS PREFRONTAL TMS vs SHAM TMS | no estimate extracted | 6 studies · 188 participants | Very low Downgraded: risk of bias, inconsistency |
Cognitive state Various measures PREFRONTAL TMS vs SHAM TMS | no estimate extracted | 4 studies · 138 participants | Low Downgraded: risk of bias, imprecision |
Adverse effects: general or specific PREFRONTAL TMS vs SHAM TMS | no estimate extracted | 7 studies · 199 participants | Low Downgraded: risk of bias |
Adverse effects: Leaving the study early PREFRONTAL TMS vs SHAM TMS | RR 1.19 [0.56, 2.5] | 8 studies · 174 participants | Low Downgraded: risk of bias, imprecision |
Satisfaction with care ‐ not reported PREFRONTAL TMS vs SHAM TMS | no estimate extracted | NR | No studies |
PREFRONTAL TBS TMS compared to SHAM TMS for schizophrenia
Population: people with schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical improvement in global state PREFRONTAL TBS TMS vs SHAM TMS | RR 4.06 [0.21, 77.37] | 1 study · 27 participants | Very low Downgraded: risk of bias, imprecision |
Global state score ‐ not reported PREFRONTAL TBS TMS vs SHAM TMS | no estimate extracted | NR | No studies |
Mental state PANSS PREFRONTAL TBS TMS vs SHAM TMS | no estimate extracted | 3 studies · 108 participants | Low Downgraded: risk of bias, imprecision |
Cognitive state Various measures PREFRONTAL TBS TMS vs SHAM TMS | no estimate extracted | 1 study · 39 participants | Low Downgraded: risk of bias, imprecision |
Adverse effects: general or specific PREFRONTAL TBS TMS vs SHAM TMS | no estimate extracted | 1 study · 27 participants | Low Downgraded: risk of bias, imprecision |
Adverse effects: Leaving the study early PREFRONTAL TBS TMS vs SHAM TMS | RR 0.36 [0.07, 1.74] | 2 studies · 76 participants | Low Downgraded: risk of bias, imprecision |
Satisfaction with care ‐ not reported PREFRONTAL TBS TMS vs SHAM TMS | no estimate extracted | NR | No studies |