Invasive fungal infection · hospitalised individuals with unknown vaccination status and a confirmed diagnosis of symptomatic COVID‐19
1 finding from 1 review
Clinical improvement: discharged alive ( · hospitalised and unvaccinated individuals with a confirmed or suspected diagnosis of symptomatic COVID‐19
Summary of findings table ‐ Corticosteroids plus standard care may leads to higher clinical improvement: discharged alive ( compared with standard care (plus/minus placebo) (low certainty).
1 finding from 1 review
Clinical worsening: new need for invasive mechanical ventilation or death · hospitalised and unvaccinated individuals with a confirmed or suspected diagnosis of symptomatic COVID‐19
Summary of findings table ‐ Corticosteroids plus standard care showed no clear difference in clinical worsening: new need for invasive mechanical ventilation or… compared with standard care (plus/minus placebo) (low certainty).
1 finding from 1 review
Serious adverse events ( · hospitalised and unvaccinated individuals with a confirmed or suspected diagnosis of symptomatic COVID‐19
1 finding from 1 review
Adverse events: all grades · hospitalised and unvaccinated individuals with a confirmed or suspected diagnosis of symptomatic COVID‐19
1 finding from 1 review
Hospital‐acquired infections ( · hospitalised and unvaccinated individuals with a confirmed or suspected diagnosis of symptomatic COVID‐19
1 finding from 1 review
Invasive fungal infection · hospitalised and unvaccinated individuals with a confirmed or suspected diagnosis of symptomatic COVID‐19
1 finding from 1 review
All‐cause mortality up to 30 days · hospitalised and unvaccinated individuals with a confirmed or suspected diagnosis of symptomatic COVID‐19
It is very uncertain whether summary of findings table ‐ Methylprednisolone changes all‐cause mortality up to 30 days compared with dexamethasone (very low certainty).
1 finding from 1 review
Oral hairy leukoplakia prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No eligible studies compared oral hairy leukoplakia between different ART regimens.
1 finding from 1 review
Gingivitis · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in gingivitis between ART regimens (very low certainty).
1 finding from 1 review
Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
cART was associated with a significantly lower prevalence of oral candidiasis than monotherapy or dual therapy (very low certainty).
1 finding from 1 review
OR 0.22 [0.16, 0.29]
4 studies
Very low
Persistent parotid enlargement prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in persistent parotid enlargement between ART regimens (very low certainty).
1 finding from 1 review
Dental caries · Individuals in Ethiopia assessed for dental caries
The presence of dental plaque was not significantly associated with dental caries (OR 5.14, 95% CI 0.67 to 39.39); certainty not graded.
1 finding from 1 review
Intervention not reported
Mean DMFT (decayed, missing, filled permanent teeth) · Individuals with permanent dentition in East Africa
Mean DMFT in Ethiopia was 1.182 (95% CI 1.135 to 1.229); certainty not graded.
1 finding from 1 review
Probing pocket depth · Adults (general and hospital populations assessed in case-control studies)
Probing depth is significantly increased in systemic sclerosis patients (SMD 3.10) with very high heterogeneity; certainty ungraded.
3 findings from 1 review
SMD 3.101 [1.374, 4.829]
7 studies
GRADE not reported
Oral manifestations of patients with systemic sclerosis: a meta-analysis for case-controlled studies. 2021 All outcomesHospital/clinic-based case-control studies from Asia, America and Europe · Other/non-Asia (Da Silva 2019, Iordache 2019, Isola 2017, Pischon 2016)
SMD 4.86 [1.61, 8.10]
4 studies
GRADE not reported
Oral manifestations of patients with systemic sclerosis: a meta-analysis for case-controlled studies. 2021 All outcomesHospital/clinic-based case-control studies from Asia, America and Europe · Asia (Elimelech 2015, Leung 2011, Mayer 2013)
SMD 1.113 [0.751, 1.476]
3 studies
GRADE not reported
Sites with probing depth >= 4 mm · Adults (general and hospital populations assessed in case-control studies)
Sites with probing depth >= 4 mm are significantly more frequent in SSc patients (SMD 2.07); certainty ungraded.
1 finding from 1 review
SMD 2.071 [0.267, 3.875]
3 studies
GRADE not reported
Intervention not reported
Mean DMFT (decayed, missing, filled permanent teeth) · Individuals with permanent dentition in East Africa
Mean DMFT was lowest in Tanzania at 0.945 (95% CI not reported); certainty not graded.
1 finding from 1 review
Periodontitis (prevalence) · Adults (general and hospital populations assessed in case-control studies)
Periodontitis prevalence is significantly higher in systemic sclerosis patients than controls (OR 7.01); certainty ungraded.
1 finding from 1 review
OR 7.007 [3.529, 13.915]
3 studies
GRADE not reported
Specificity · Oral cavity cancer or potentially malignant disorder symptom-free individuals with tobacco habits
2 findings from 1 review
Specificity 0.91 [0.90, 0.91]
1 study · 4080 participants
Moderate
Specificity 0.92 [0.91, 0.93]
1 study · 3895 participants
Moderate
Mean number of decayed teeth (mean DT) · Adults (general and hospital populations assessed in case-control studies)
Systemic sclerosis patients have a significantly higher number of decayed teeth than controls (SMD 0.19); certainty ungraded.
1 finding from 1 review
SMD 0.186 [0.007, 0.365]
3 studies
GRADE not reported