Search review questions

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Self-Etch + chemical ACAD

Sensitivity · Patients undergoing dental caries detection on dental images (teeth/surfaces across imaging modalities) · Cross-sectional diagnostic accuracy (index test vs reference standard), Overall (all imaging modalities pooled)

Fracture of lumbar spine and pelvis · European-ancestry adults · Lifelong genetic liability, MVMR (IVW), adjusted for periodontitis

Negative oral-health impact on daily performance measured by OIDP · Adolescents aged 10 to 19 years · Cross-sectional (concurrent exposure and outcome); oral impacts recalled over the prior 6 months, Instrument subgroup: OIDP (all 3 studies)

Early childhood caries (ECC) · Children aged 0-5 years in North Africa

Patients' factors of choice regarding utilization of dental treatments · Potential patients in dental care, including parents or caregivers making treatment decisions; excludes patients with…

TNF-α level · People who use electronic cigarettes · Overall

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Etch-and-Rinse + chemical ACAD

Caries experience (mean DMFT) · 12-year-old children across European countries (national/regional epidemiological surveys, 2011-2022) · Cross-sectional (survey data 2011-2022), East Europe

Fracture of forearm · European-ancestry adults · Lifelong genetic liability, MVMR (IVW), adjusted for periodontitis

Early childhood caries (ECC) · Children aged 0-5 years in North Africa

Early childhood caries (ECC), prevalence · Study design: hospital-based

Clinical and radiographic success rate · Adults aged 18 years or older with mature permanent teeth and carious pulp exposure · Per day of restoration delay, Meta-regression

Dental caries (presence) · Children and adolescents (0-18 years; most included reviews focused on <6 years)

Early childhood caries (ECC) · Children aged 0-5 years in North Africa

Amalgam: Preference for replacement over repair - Scenario 2: loss of dental hard substance adjacent to the restoration · HDI: High

Treatment success (caries lesion arrest or restoration survival) · Children (aged 3-11 y) with cavitated caries lesions in primary teeth · 12 months, 12-month follow-up

Amalgam: Preference for replacement over repair - Scenario 5: open margin · Coverage: Covering cost of minimally invasive treatment

Composite: Preference for replacement over repair - Scenario 2: loss of dental hard substance adjacent to the restoration · Dentists managing a defective direct resin composite restoration (posterior occlusal Class I; standardized vignette of… · Not applicable (single time-point survey, June to October 2023), Overall (all 21 countries pooled)

Composite: Preference for replacement over repair - Scenario 2: loss of dental hard substance adjacent to the restoration · Continent: Africa

Amalgam: Preference for replacement over repair - Scenario 3: secondary caries · Continent: Asia

Tooth survival · Patients with deep caries lesions in mature or immature permanent (posterior) teeth, with no symptoms or reversible… · >=12 months

Composite: Preference for replacement over repair - Scenario 5: open margin · HDI: Low

Composite: Preference for replacement over repair - Scenario 5: open margin · Dentists managing a defective direct resin composite restoration (posterior occlusal Class I; standardized vignette of… · Not applicable (single time-point survey, June to October 2023), Overall (all 21 countries pooled)

Risk of fragility fractures · Females (all ages) · Long-term / lifetime fluoride exposure, Females: drinking-water fluoride 1.1 mg/L vs null

Femur fracture · European GWAS participants · SVMR MR-Egger

Occlusal caries detection: sensitivity · Extracted human teeth (in vitro); permanent and primary teeth, occlusal surfaces · Primary dentition

Osteoporosis with pathological fracture · European-ancestry adults · Lifelong genetic liability, SVMR (IVW), total causal effect

Amalgam: Preference for replacement over repair - Scenario 3: secondary caries · HDI: High

Composite: Preference for replacement over repair - Scenario 4: marginal discoloration · HDI: High

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Self-Etch + biological ACAD

Oral health-related quality of life (OHRQoL) · Children and adolescents aged 5-18 years · Post-intervention (follow-up 0.5 to 12 months, varies by study), Overall

Negative oral-health impact on daily performance measured by OIDP · Adolescents aged 10 to 19 years · Cross-sectional (concurrent exposure and outcome); oral impacts recalled over the prior 6 months, Instrument subgroup: OIDP, sensitivity analysis excluding Krisdapong et al.

Amalgam: Preference for replacement over repair - Scenario 6: corrosion · HDI: Low

Absence of secondary caries · Children receiving dental restorations (aged 4-11 years; primary teeth; Class I/II/V cavities) · 1 to 2 years

Amalgam: Preference for replacement over repair - Scenario 6: corrosion · Continent: Africa

Amalgam: Preference for replacement over repair - Scenario 3: secondary caries · HDI: Low

Clinical and radiographic success · Vital permanent teeth (mature or immature) with deep or extremely deep caries and asymptomatic pulp or reversible… · >=12 months

Salivary Streptococcus mutans count · Children aged 6 to 12 years · 4 weeks

Clinical and radiographic success · Vital permanent teeth (mature or immature) with deep or extremely deep caries and asymptomatic pulp or reversible… · 12 months, 12-month follow-up

Lumbar spine and pelvis fracture · European GWAS participants · SVMR Weighted Median

Amalgam: Preference for replacement over repair - Scenario 2: loss of dental hard substance adjacent to the restoration · Dentists managing a defective direct amalgam restoration (posterior occlusal Class I; standardized vignette of a… · Not applicable (single time-point survey, June to October 2023), Overall (all 21 countries pooled)

Postmenopausal osteoporosis with pathological fracture · Postmenopausal women (European ancestry) · Lifelong genetic liability, MVMR (IVW), adjusted for periodontitis

Composite: Preference for replacement over repair - Scenario 4: marginal discoloration · Continent: Africa

Amalgam: Preference for replacement over repair - Scenario 6: corrosion · Dentists managing a defective direct amalgam restoration (posterior occlusal Class I; standardized vignette of a… · Not applicable (single time-point survey, June to October 2023), Overall (all 21 countries pooled)

Amalgam: Preference for replacement over repair - Scenario 5: open margin · Coverage: Not covering

Log diagnostic odds ratio · Imaging modality: Bitewing radiographs

Prevalence of early childhood caries · Children up to 71 months · More than 24 months

Fear of SARS-CoV-2 infection (COVID-19) as a barrier to dental treatment · (Potential) patients with freedom of choice regarding dental treatments, including parents and caregivers deciding for… · US patients surveyed at COVID-19 onset (Papautsky et al., n=2570)

Amalgam: Preference for replacement over repair - Scenario 4: marginal discoloration · Dentists managing a defective direct amalgam restoration (posterior occlusal Class I; standardized vignette of a… · Not applicable (single time-point survey, June to October 2023), HDI: Very high