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Evidence found and GRADE certainty

4,345 questions · 4,525 findings · 483 reviews

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No studies found 1,024 · 22.6%GRADE not reported 388 · 8.6%Very low 1,172 · 25.9%Low 1,227 · 27.1%Moderate 576 · 12.7%High 138 · 3%

Surgery vs oral medication

Control of bleeding (cure or improvement to acceptable level) At 2 years · women with heavy menstrual bleeding

Surgery probably leads to higher control of bleeding (cure or improvement to acceptable level) At 4… compared with oral medication (moderate certainty).

3 findings from 1 review

Surgery vs LNG‐IUS

Proportion of women with adverse events Endometrial ablation versus LNG‐IUS. At one year · women with heavy menstrual bleeding

Surgery probably leads to lower proportion of women with adverse events Endometrial ablation versus… compared with LNG‐IUS (moderate certainty).

1 finding from 1 review

Surgery vs oral medication

Overall satisfaction with treatment At 5 years · women with heavy menstrual bleeding

It is very uncertain whether surgery changes overall satisfaction with treatment At 5 years compared with oral medication (very low certainty).

1 finding from 1 review

Surgery vs LNG‐IUS

Objective control of bleeding: menstrual loss under 80 ml per cycle LNG‐IUS versus hysterectomy At 1 year · women with heavy menstrual bleeding

Surgery probably leads to higher objective control of bleeding: menstrual loss under 80 ml per cycle… compared with LNG‐IUS (moderate certainty).

1 finding from 1 review

Surgery vs LNG‐IUS

Subjective control of bleeding: PBAC no more than 75 per cycle Endometrial resection or ablation versus LNG‐IUS At 1 year · women with heavy menstrual bleeding

Surgery may leads to higher subjective control of bleeding: PBAC no more than 75 per cycle… compared with LNG‐IUS (low certainty).

1 finding from 1 review

Induction chemotherapy plus locoregional treatment (radiotherapy and/or surgery) vs Locoregional treatment (radiotherapy and/or surgery) alone

Overall survival, induction platinum + 5-fluorouracil prior to surgery vs surgery alone · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Induction chemotherapy plus locoregional treatment (radiotherapy… showed no clear difference in overall survival, induction platinum + 5-fluorouracil prior to… compared with locoregional treatment (radiotherapy and/or surgery) alone (low certainty).

1 finding from 1 review

Vaginal POP surgery with armed mesh vs anterior native tissue repair

One type of POP surgery vs another: armed anterior mesh vs anterior native tissue repair · continent women with POP

Vaginal POP surgery with armed mesh may leads to higher one type of POP surgery vs another: armed anterior mesh vs anterior… compared with anterior native tissue repair (low certainty).

1 finding from 1 review

Surgery with excision of failed tape vs surgery without excision of tape

Number of women whose incontinence was improved or cured ‐ · women with recurrent stress urinary incontinence after failed minimally invasive midurethral tape surgery

The review found no eligible studies for this question.

1 finding from 1 review

Surgery with excision of failed tape vs surgery without excision of tape

Objective cure rates in the longer‐term ‐ more than 12 months, · women with recurrent stress urinary incontinence after failed minimally invasive midurethral tape surgery

The review found no eligible studies for this question.

1 finding from 1 review

Surgery with excision of failed tape vs surgery without excision of tape

General health status evaluation e.g. Short Form (SF)‐36 ‐ not reported · women with recurrent stress urinary incontinence after failed minimally invasive midurethral tape surgery

The review found no eligible studies for this question.

1 finding from 1 review

Surgery with excision of failed tape vs surgery without excision of tape

Condition‐specific instruments designed to assess incontinence ‐ e.g. BFLUTS · women with recurrent stress urinary incontinence after failed minimally invasive midurethral tape surgery

The review found no eligible studies for this question.

1 finding from 1 review

POP surgery with concomitant continence procedure vs no concomitant continence procedure

Vaginal POP surgery with vs without MUS · women with POP and SUI

POP surgery with concomitant continence procedure probably leads to lower vaginal POP surgery with vs without MUS compared with no concomitant continence procedure (moderate certainty).

2 findings from 1 review

POP surgery with concomitant continence procedure vs no concomitant continence procedure

Vaginal POP surgery with concomitant vs delayed continence surgery: additional concomitant MUS vs delayed MUS · women with POP and SUI

POP surgery with concomitant continence procedure showed no clear difference in vaginal POP surgery with concomitant vs delayed continence surgery:… compared with no concomitant continence procedure (moderate certainty).

1 finding from 1 review

POP surgery with concomitant continence procedure vs no concomitant continence procedure

Abdominal POP surgery with or without concomitant continence surgery: additional Burch colposuspension vs sacrocolpopexy alone · women with POP and SUI

POP surgery with concomitant continence procedure showed no clear difference in abdominal POP surgery with vs without concomitant continence… compared with no concomitant continence procedure (moderate certainty).

1 finding from 1 review