What do systematic reviews say?

Laparoscopic vs open surgery

• Laparoscopic repair for perforated peptic ulcer disease 2013 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 214 participants
  Very low

Phacoemulsification + supraciliary microstent surgery vs phacoemulsification alone

Phacoemulsification + supraciliary microstent surgery probably leads to higher proportion of participants who were medication‐free (not using… compared with phacoemulsification alone (moderate certainty).

• Ab interno supraciliary microstent surgery for open‐angle glaucoma 2021 · Cochrane Headline outcomes only
  RR 1.27 [1.09, 1.49]
  1 study · 448 participants
  Moderate

Phacoemulsification + supraciliary microstent surgery vs phacoemulsification alone

Phacoemulsification + supraciliary microstent surgery showed no clear difference in mean change in unmedicated IOP24 months (medium‐term) compared with phacoemulsification alone (high certainty).

• Ab interno supraciliary microstent surgery for open‐angle glaucoma 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 448 participants
  High

Phacoemulsification + supraciliary microstent surgery vs phacoemulsification alone

Phacoemulsification + supraciliary microstent surgery showed no clear difference in mean change in daily IOP‐lowering medicationsat 24 months… compared with phacoemulsification alone (moderate certainty).

• Ab interno supraciliary microstent surgery for open‐angle glaucoma 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 448 participants
  Moderate

Phacoemulsification + supraciliary microstent surgery vs phacoemulsification alone

The review found no eligible studies for this question.

• Ab interno supraciliary microstent surgery for open‐angle glaucoma 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Phacoemulsification + supraciliary microstent surgery vs phacoemulsification alone

The review found no eligible studies for this question.

• Ab interno supraciliary microstent surgery for open‐angle glaucoma 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Phacoemulsification + supraciliary microstent surgery vs phacoemulsification alone

Phacoemulsification + supraciliary microstent surgery showed no clear difference in proportion of participants experiencing postoperative… compared with phacoemulsification alone (moderate certainty).

• Ab interno supraciliary microstent surgery for open‐angle glaucoma 2021 · Cochrane Headline outcomes only
  RR 1.1 [0.8, 1.4]
  1 study · 505 participants
  Moderate

Open TMJ surgery (arthroplasty / total joint replacement)

The review found no eligible studies for this question.

• Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes
  No study evaluated open surgery for TMJ OA, which should be explored in future trials (Research recommendations Table 1; Discussion).
  0 studies
  No studies found

Tranexamic acid vs placebo

The review found no eligible studies for this question.

• Drugs to reduce bleeding and transfusion in major open vascular or endovascular surgery: a systematic review and… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings: Fibrin sealant vs usual care

The review found no eligible studies for this question.

• Drugs to reduce bleeding and transfusion in major open vascular or endovascular surgery: a systematic review and… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Phaco‐AIT vs Phaco‐Trab

It is very uncertain whether phaco‐AIT changes proportion of participants who required further glaucoma surgery at… compared with phaco‐Trab (very low certainty).

• Ab interno trabecular bypass surgery with Trabectome for open‐angle glaucoma 2021 · Cochrane Headline outcomes only
  OR 3
  1 study · 18 participants
  Very low

Hydrus microstent vs iStent trabecular micro‐bypass stent

• Ab interno trabecular bypass surgery with Schlemm´s canal microstent (Hydrus) for open angle glaucoma 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 148 participants
  Very low

IStent (or iStent inject) vs medical therapy

• Ab interno trabecular bypass surgery with iStent for open‐angle glaucoma 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 286 participants
  GRADE not reported

IStent in combination with phacoemulsification vs phacoemulsification alone

• Ab interno trabecular bypass surgery with iStent for open‐angle glaucoma 2019 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 290 participants
  GRADE not reported

Rotary instruments to open the lateral sinus window vs Piezosurgery to open the lateral sinus window

• Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus 2014 · Cochrane All outcomes

  1 year after loading
  Rickert 2013 (N = 36): no complications at donor site.
  1 study · 36 participants
  GRADE not reported

Rotary instruments to open the lateral sinus window vs Piezosurgery to open the lateral sinus window

• Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus 2014 · Cochrane All outcomes

  1 year after loading
  Rickert 2013 (split-mouth, N = 36): no prosthesis failures in either group.
  1 study · 36 participants
  GRADE not reported

Rotary instruments to open the lateral sinus window vs Piezosurgery to open the lateral sinus window

• Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus 2014 · Cochrane All outcomes

  1 year after loading
  Rickert 2013 (N = 36): no augmentation procedure failures.
  1 study · 36 participants
  GRADE not reported

Rotary instruments to open the lateral sinus window vs Piezosurgery to open the lateral sinus window

• Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus 2014 · Cochrane All outcomes

  1 year after loading
  Rickert 2013 (N = 36): no implant failures in either group.
  1 study · 36 participants
  GRADE not reported

Rotary instruments to open the lateral sinus window vs Piezosurgery to open the lateral sinus window

Rotary instruments to open the lateral sinus window showed no clear difference in complications at augmented site compared with piezosurgery to open the lateral sinus window; GRADE not reported.

• Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus 2014 · Cochrane All outcomes

  1 year after loading
  OR 1.00 [0.27, 3.74]
  1 study · 36 participants
  GRADE not reported

Thiopentone and ketamine vs benzodiazepines

It is very uncertain whether thiopentone and ketamine changes awareness Postoperative interview compared with benzodiazepines (diazepam, midazolam, lorazepam) (very low certainty).

• Anaesthetic interventions for prevention of awareness during surgery 2016 · Cochrane Headline outcomes only
  RR 0.17 [0.02, 0.25]
  4 studies · 291 participants
  Very low