Cochrane · systematic review · CD007272
Anaesthetic interventions for prevention of awareness during surgery
Messina, AG, Wang, M, Ward, MJ, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
AnaesthesiaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
11
current version
GRADE rated
6
No studies
5
Included studies
NR
No studies 5 · 45.5%Ungraded 0 · 0%Very low 2 · 18.2%Low 4 · 36.4%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Anaesthesia depth monitors (BIS and M‐entropy) versus standard clinical and electronic monitoring
Population: patients with prevention of recall of events during surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Awareness Postoperative interview Anaesthesia depth monitors (BIS and M‐entropy) vs standard clinical and electronic monitoring | OR 0.98 [0.59, 1.62] | 9 studies · 34744 participants | Low Downgraded: imprecision, inconsistency |
Adverse effects of intraoperative wakefulness and/or postoperative awareness (i.e. post‐traumatic stress syndrome, myocardial infarction, cardiac arrest, etc.) Anaesthesia depth monitors (BIS and M‐entropy) vs standard clinical and electronic monitoring | no estimate extracted | NR | No studies |
Anaesthesia depth monitors (BIS) versus standard clinical and electronic monitoring
Population: patients with prevention of recall of events during surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Awareness: definite and possible Postoperative interview Anaesthesia depth monitors (BIS) vs standard clinical and electronic monitoring | OR 0.96 [0.35, 2.65] | 5 studies · 34181 participants | Low Downgraded: imprecision, inconsistency |
Awareness: definite Postoperative interview Anaesthesia depth monitors (BIS) vs standard clinical and electronic monitoring | OR 0.6 [0.13, 2.75] | 5 studies · 34181 participants | Low Downgraded: inconsistency |
Adverse effects of intraoperative wakefulness and/or postoperative awareness (i.e. post‐traumatic stress syndrome, myocardial infarction, cardiac arrest, etc.) Anaesthesia depth monitors (BIS) vs standard clinical and electronic monitoring | no estimate extracted | NR | No studies |
Thiopentone with and without added hypnotic drugs (ketamine, etomidate)
Population: patients with prevention of recall of events during surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intraoperative Wakefulness Postoperative Interview | RR 0.18 [0.09, 0.41] | 3 studies · 141 participants | Low Downgraded: risk of bias, imprecision |
Adverse effects of intraoperative wakefulness and/or postoperative awareness (i.e. post‐traumatic stress syndrome, myocardial infarction, cardiac arrest, etc.) | no estimate extracted | NR | No studies |
Thiopentone and ketamine versus benzodiazepines (diazepam, midazolam, lorazepam)
Population: patients with prevention of recall of events during surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Awareness Postoperative interview Thiopentone and ketamine vs benzodiazepines (diazepam, midazolam, lorazepam) | RR 0.17 [0.02, 0.25] | 4 studies · 291 participants | Very low Downgraded: risk of bias, imprecision |
Adverse effects of intraoperative wakefulness and/or postoperative awareness (i.e. post‐traumatic stress syndrome, myocardial infarction, cardiac arrest, etc.) Thiopentone and ketamine vs benzodiazepines (diazepam, midazolam, lorazepam) | no estimate extracted | NR | No studies |
Caesarean section with low‐ and high‐dose inhaled agent
Population: patients with decreasing recall of events during surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Awareness Postoperative interview1 | RR 0.13 [0.04, 0.43] | 2 studies · 858 participants | Very low Downgraded: risk of bias, imprecision |
Adverse effects of intraoperative wakefulness and/or postoperative awareness (i.e. post‐traumatic stress syndrome, myocardial infarction, cardiac arrest, etc.) | no estimate extracted | NR | No studies |