What do systematic reviews say?

Inhaled corticosteroids vs placebo

Inhaled corticosteroids showed no clear difference in pseudomonas aeruginosa (P aeruginosa) colonisation compared with placebo (low certainty).

• Inhaled corticosteroids for bronchiectasis 2018 · Cochrane Headline outcomes only
  OR 0.94 [0.45, 1.96]
  2 studies · 156 participants
  Low

NMES and exercise vs exercise (with or without sham NMES)

• Neuromuscular electrostimulation for adults with chronic obstructive pulmonary disease 2018 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 144 participants
  Low

NMES vs usual care with or without sham interventions

NMES showed no clear difference in minor adverse events assessed: related to intervention only (e.g.… compared with usual care (with or without sham NMES) (low certainty).

• Neuromuscular electrostimulation for adults with chronic obstructive pulmonary disease 2018 · Cochrane Headline outcomes only
  RD 0
  5 studies · 139 participants
  Low

Oral + inhaled dual therapy vs oral monotherapy

It is very uncertain whether oral + inhaled dual therapy changes successful treatment of exacerbation: number of participants with P… compared with oral monotherapy (very low certainty).

• Dual antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  OR 2.33 [0.66, 8.24]
  1 study · 53 participants
  Very low

Intervention not reported

The intervention showed no clear difference in severe exacerbations requiring hospitalisation over the study period (low certainty).

• Culture‐specific programs for children and adults from minority groups who have asthma 2017 · Cochrane Headline outcomes only
  OR 1.55 [0.6, 3.66]
  1 study · 88 participants
  Low

Intervention not reported

• Culture‐specific programs for children and adults from minority groups who have asthma 2017 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 110 participants
  Low

Intervention not reported

It is very uncertain whether the intervention changes number of participants who had one or more exacerbation of the study… (very low certainty).

• Culture‐specific programs for children and adults from minority groups who have asthma 2017 · Cochrane Headline outcomes only
  OR 0.8 [0.5, 1.26]
  1 study · 294 participants
  Very low

Intervention not reported

It is very uncertain whether the intervention changes number of participants requiring oral corticosteroids over the study… (very low certainty).

• Culture‐specific programs for children and adults from minority groups who have asthma 2017 · Cochrane Headline outcomes only
  OR 0.97 [0.55, 1.73]
  1 study · 294 participants
  Very low

Intervention not reported

It is very uncertain whether the intervention changes severe exacerbations requiring hospitalisation over the study period (very low certainty).

• Culture‐specific programs for children and adults from minority groups who have asthma 2017 · Cochrane Headline outcomes only
  OR 0.83 [0.31, 2.22]
  1 study · 294 participants
  Very low

IV beta‐agonists vs IV aminophylline

• Intravenous beta₂‐agonists versus intravenous aminophylline for acute asthma 2012 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 73 participants
  Moderate

IV beta‐agonists vs IV aminophylline

• Intravenous beta₂‐agonists versus intravenous aminophylline for acute asthma 2012 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 59 participants
  Moderate

IV beta‐agonists vs IV aminophylline

• Intravenous beta₂‐agonists versus intravenous aminophylline for acute asthma 2012 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 59 participants
  Moderate

IV beta‐agonists vs IV aminophylline

• Intravenous beta₂‐agonists versus intravenous aminophylline for acute asthma 2012 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 82 participants
  Low

IV beta‐agonists vs IV aminophylline

• Intravenous beta₂‐agonists versus intravenous aminophylline for acute asthma 2012 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 89 participants
  Moderate

Polymyxins vs aminoglycosides

It is very uncertain whether polymyxins changes response rate ‐ improvement in sputum purulence compared with aminoglycosides (very low certainty).

• Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  OR 0.16 [0.01, 3.85]
  1 study · 20 participants
  Very low

Polymyxins vs aminoglycosides

• Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 20 participants
  Very low

Polymyxins vs aminoglycosides

The review found no eligible studies for this question.

• Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Polymyxins vs aminoglycosides

The review found no eligible studies for this question.

• Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Polymyxins vs aminoglycosides

• Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 20 participants
  Very low

Alteplase vs urokinase

Alteplase showed no clear difference in referral for thoracic surgery (open or thorascopic) compared with urokinase (low certainty).

• Intra‐pleural fibrinolytic therapy versus placebo, or a different fibrinolytic agent, in the treatment of adult… 2019 · Cochrane Headline outcomes only
  OR 0.46 [0.04, 5.24]
  1 study · 99 participants
  Low