Cochrane · systematic review · CD000996
Inhaled corticosteroids for bronchiectasis
Kapur, N, Petsky, HL, Bell, S, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
10
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 10 · 100%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Inhaled corticosteroids compared to placebo for bronchiectasis (short‐term use of 6 months or less)
Population: people with bronchiectasis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Lung function (spirometry indices) ‐ FEV1 (in L, end study minus baseline values) Inhaled corticosteroids vs placebo | no estimate extracted | 2 studies · 156 participants | Low Downgraded: imprecision |
Lung function (spirometry indices) ‐ FVC (in L, end study minus baseline values) Inhaled corticosteroids vs placebo | no estimate extracted | 2 studies · 156 participants | Low Downgraded: imprecision |
Lung function (other indices) ‐ diffusion capacity % predicted (end of study) Inhaled corticosteroids vs placebo | no estimate extracted | 1 study · 57 participants | Low Downgraded: imprecision |
Lung function (other indices) ‐ RV % predicted (end of study values) Inhaled corticosteroids vs placebo | no estimate extracted | 1 study · 57 participants | Low Downgraded: imprecision |
Lung function (other indices) ‐ TLC % predicted (end of study values) Inhaled corticosteroids vs placebo | no estimate extracted | 1 study · 57 participants | Low Downgraded: imprecision |
Average number of exacerbations per participant Inhaled corticosteroids vs placebo | no estimate extracted | 2 studies · 127 participants | Low Downgraded: imprecision |
Pseudomonas aeruginosa (P aeruginosa) colonisation Inhaled corticosteroids vs placebo | OR 0.94 [0.45, 1.96] | 2 studies · 156 participants | Low Downgraded: imprecision |
Inhaled corticosteroids compared to placebo for bronchiectasis (longer‐term use of > 6 months)
Population: people with bronchiectasis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Lung function indices ‐ FEV1% predicted (end study minus baseline values) Inhaled corticosteroids vs placebo | no estimate extracted | 1 study · 86 participants | Low Downgraded: risk of bias, imprecision |
Lung function indices ‐ FVC % predicted (end study minus baseline values) Inhaled corticosteroids vs placebo | no estimate extracted | 1 study · 86 participants | Low Downgraded: risk of bias, imprecision |
Number of participants improved Inhaled corticosteroids vs placebo | OR 0.57 [0.24, 1.34] | 1 study · 86 participants | Low Downgraded: risk of bias, imprecision |