Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

216 questions · 257 findings · 27 reviews · All outcomes

No studies found 29 · 11.3%GRADE not reported 162 · 63%Very low 30 · 11.7%Low 19 · 7.4%Moderate 12 · 4.7%High 5 · 1.9%

Topical triamcinolone acetonide vs Hyaluronic acid gel

Pain (mean score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical triamcinolone acetonide showed no clear difference in pain (mean score) compared with hyaluronic acid gel; GRADE not reported.

1 finding from 1 review

Topical triamcinolone acetonide vs Cryotherapy

Pain (mean score, split-mouth) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether topical triamcinolone acetonide changes pain (mean score, split-mouth) compared with cryotherapy (very low certainty).

1 finding from 1 review

Topical triamcinolone acetonide vs Topical ciclosporin

Pain (mean VAS score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical triamcinolone acetonide showed no clear difference in pain (mean VAS score) compared with topical ciclosporin; GRADE not reported.

1 finding from 1 review

Topical triamcinolone acetonide vs pimecrolimus 1%

Pain (mean VAS score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical triamcinolone acetonide showed no clear difference in pain (mean VAS score) compared with topical pimecrolimus; GRADE not reported.

1 finding from 1 review

Topical triamcinolone acetonide vs Photodynamic therapy

Pain (mean score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether topical triamcinolone acetonide changes pain (mean score) compared with photodynamic therapy (very low certainty).

1 finding from 1 review

CAD/CAM nitinol fixed (bonded) retainer vs Multistrand / spiral wire fixed (bonded) retainer

Survival of retainers (failure, lower arch) · People who had received fixed appliance orthodontic treatment

It is very uncertain whether CAD/CAM nitinol fixed (bonded) retainer changes survival of retainers (failure, lower arch) compared with conventional/analogue multistrand fixed (bonded) retainer (very low certainty).

1 finding from 1 review

CAD/CAM nitinol fixed (bonded) retainer vs Multistrand / spiral wire fixed (bonded) retainer

Adverse effects on oral health: Gingival Index (lower arch) · People who had received fixed appliance orthodontic treatment

CAD/CAM nitinol fixed (bonded) retainer showed no clear difference in adverse effects on oral health: Gingival Index (lower arch) compared with conventional/analogue multistrand fixed (bonded) retainer (low certainty).

1 finding from 1 review

CAD/CAM nitinol fixed (bonded) retainer vs Multistrand / spiral wire fixed (bonded) retainer

Adverse effects on oral health: bleeding on probing (lower arch) · People who had received fixed appliance orthodontic treatment

The review found no eligible studies for this question.

1 finding from 1 review

CAD/CAM nitinol fixed (bonded) retainer vs Multistrand / spiral wire fixed (bonded) retainer

Stability: Little's Irregularity Index (lower arch) · People who had received fixed appliance orthodontic treatment

It is very uncertain whether CAD/CAM nitinol fixed (bonded) retainer changes stability: Little's Irregularity Index (lower arch) compared with conventional/analogue multistrand fixed (bonded) retainer (very low certainty).

1 finding from 1 review

Preoperative paracetamol (acetaminophen) vs placebo

Postoperative pain (dichotomous measure: parent report of presence of pain-related behaviours) · Children and adolescents having dental treatment under local anaesthetic (restorative and extraction treatments)

Preoperative paracetamol (acetaminophen) showed no clear difference in postoperative pain (dichotomous measure: parent report of presence… compared with placebo (low certainty).

1 finding from 1 review

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs Chlorhexidine mouthwash

Oral mucositis (any severity) · Children with acute lymphoblastic leukaemia receiving chemotherapy alone

Keratinocyte growth factor (KGF), intravenous led to lower oral mucositis (any severity) compared with chlorhexidine mouthwash; GRADE not reported.

1 finding from 1 review

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs Chlorhexidine mouthwash

Oral mucositis (moderate to severe) · Children with acute lymphoblastic leukaemia receiving chemotherapy alone

Keratinocyte growth factor (KGF), intravenous led to lower oral mucositis (moderate to severe) compared with chlorhexidine mouthwash; GRADE not reported.

1 finding from 1 review