Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

339 questions · 346 findings · 42 reviews · Headline outcomes only

No studies found 74 · 21.4%GRADE not reported 8 · 2.3%Very low 72 · 20.8%Low 107 · 30.9%Moderate 68 · 19.7%High 17 · 4.9%

Oral calcium vs no treatment

Frequency of leg cramps after treatment: never · treating leg cramps in pregnancy

It is very uncertain whether oral calcium changes frequency of leg cramps after treatment: never compared with no treatment (very low certainty).

2 findings from 1 review

Oral calcium vs vitamin C

Frequency of leg cramps after treatment: never · treating leg cramps in pregnancy

It is very uncertain whether oral calcium changes frequency of leg cramps after treatment: never compared with oral vitamin C (very low certainty).

1 finding from 1 review

Vitamin D plus calcium vs vitamin D

Adverse events (number) Asymptomatic hypercalcaemia and hypercalciuria

It is very uncertain whether vitamin D plus calcium changes adverse events (number) Definition: asymptomatic hypercalcaemia and… compared with vitamin D (very low certainty).

1 finding from 1 review

Vitamin D plus calcium vs vitamin D

Healing of rickets (number) Definition: normal alkaline phosphatase and bone radiograph

Vitamin D plus calcium may leads to higher healing of rickets (number) Definition: normal alkaline phosphatase… compared with vitamin D (low certainty).

1 finding from 1 review

Calcium supplementation/fortification vs placebo (outcomes

Pre‐eclampsia · women who are not yet pregnant and women in the early stages of pregnancy

Calcium supplementation showed no clear difference in pre‐eclampsia compared with placebo (maternal outcomes) commencing before or early (low certainty).

1 finding from 1 review

Calcium supplementation/fortification vs placebo (outcomes

Pre‐eclampsia, or pregnancy loss, or stillbirth (or combination) at any gestational age · women who are not yet pregnant and women in the early stages of pregnancy

Calcium supplementation showed no clear difference in pre‐eclampsia, or pregnancy loss, or stillbirth (or combination) at… compared with placebo (maternal outcomes) commencing before or early (low certainty).

1 finding from 1 review

Calcium supplementation/fortification vs placebo (outcomes

Severe maternal morbidity and mortality index · women who are not yet pregnant and women in the early stages of pregnancy

Calcium supplementation showed no clear difference in severe maternal morbidity and mortality index compared with placebo (maternal outcomes) commencing before or early (low certainty).

1 finding from 1 review

Calcium supplementation/fortification vs placebo (outcomes

Pregnancy loss or stillbirth at any gestational age · women who are not yet pregnant and women in the early stages of pregnancy

Calcium supplementation showed no clear difference in pregnancy loss or stillbirth at any gestational age compared with placebo (maternal outcomes) commencing before or early (low certainty).

1 finding from 1 review

Calcium supplementation/fortification vs placebo (outcomes

Caesarean section · women who are not yet pregnant and women in the early stages of pregnancy

Calcium supplementation showed no clear difference in caesarean section compared with placebo (maternal outcomes) commencing before or early (low certainty).

1 finding from 1 review