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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
1,956 questions in 143 reviews · Musculoskeletal
current versionsNo studies 555 · 28.4%Ungraded 107 · 5.5%Very low 255 · 13%Low 555 · 28.4%Moderate 357 · 18.3%High 127 · 6.5%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Eye drop dispenser device vs standard bottle Adverse events ‐ Touching the eye with the bottle tip · patients with rheumatoid arthritis Assistive technology for rheumatoid arthritis (2009) · Cochrane | RR 0.01 [0, 0.1] | 1 study · 58 participants | Low |
Intervention NR Functional ability HAQ . Scale from: 0 to 3. · patients with Rheumatoid Arthritis Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid… (2009) · Cochrane | no estimate extracted | 1 study · 50 participants | Moderate |
Intervention NR Disease activity · patients with Rheumatoid Arthritis Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid… (2009) · Cochrane | no estimate extracted | 0 studies · 3 participants | Low |
Intervention NR Radiological damage ‐ not measured · patients with Rheumatoid Arthritis Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid… (2009) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Functional ability outcome was measured on different scales in different studies · patients with Rheumatoid Arthritis Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid… (2009) · Cochrane | no estimate extracted | 2 studies · 88 participants | Moderate |
Intervention NR Muscle strenght Grip strength · patients with Rheumatoid Arthritis Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid… (2009) · Cochrane | no estimate extracted | 1 study · 20 participants | Low |
Intervention NR Self‐reported pain AIMS. Scale from: 0 to 10. · patients with Rheumatoid Arthritis Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid… (2009) · Cochrane | no estimate extracted | 1 study · 68 participants | Moderate |
Intervention NR Disease activity · patients with Rheumatoid Arthritis Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid… (2009) · Cochrane | no estimate extracted | 2 studies · 88 participants | Moderate |
Intervention NR Radiological damage ‐ not measured · patients with Rheumatoid Arthritis Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid… (2009) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Small patient number · patients with Rheumatoid Arthritis Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid… (2009) · Cochrane | no estimate extracted | 1 participants | Ungraded |
Intervention NR Functional ability outcome was measured on different scales in different studies · patients with patients with Rheumatoid Arthritis Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid… (2009) · Cochrane | no estimate extracted | 2 studies · 305 participants | High |
Intervention NR Muscle strength Isometric extension · patients with patients with Rheumatoid Arthritis Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid… (2009) · Cochrane | no estimate extracted | 2 studies · 305 participants | High |
Intervention NR Muscle strength Isometric extension · patients with Rheumatoid Arthritis Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid… (2009) · Cochrane | no estimate extracted | 2 studies · 74 participants | Moderate |
Intervention NR Self‐reported pain VAS. Scale from: 0 to 10. · patients with patients with Rheumatoid Arthritis Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid… (2009) · Cochrane | no estimate extracted | 1 study · 24 participants | Low |
Intervention NR Disease activity DAS · patients with patients with Rheumatoid Arthritis Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid… (2009) · Cochrane | no estimate extracted | 1 study · 281 participants | High |
Intervention NR Radiological damage Joint score radiographics · patients with patients with Rheumatoid Arthritis Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid… (2009) · Cochrane | no estimate extracted | 2 studies · 305 participants | High |
Intervention NR Small patient number · patients with patients with Rheumatoid Arthritis Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid… (2009) · Cochrane | no estimate extracted | 1 participants | Ungraded |
Intervention NR Self‐reported pain VAS. Scale from: 0 to 10. · patients with Rheumatoid Arthritis Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid… (2009) · Cochrane | no estimate extracted | 1 study · 50 participants | Moderate |
Intervention NR Disease activity · patients with Rheumatoid Arthritis Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid… (2009) · Cochrane | no estimate extracted | 2 studies · 74 participants | Moderate |
Intervention NR Radiological damage ‐ not measured · patients with Rheumatoid Arthritis Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid… (2009) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Small patient number · patients with Rheumatoid Arthritis Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid… (2009) · Cochrane | no estimate extracted | 1 participants | Ungraded |
Intervention NR Functional ability AIMS . Scale from: 0 to 10. · patients with Rheumatoid Arthritis Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid… (2009) · Cochrane | no estimate extracted | 1 study · 56 participants | Low |
Intervention NR Muscle strength Isometric extension · patients with Rheumatoid Arthritis Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid… (2009) · Cochrane | no estimate extracted | 1 study · 10 participants | Low |
Intervention NR Self‐reported pain AIMS. Scale from: 0 to 10. · patients with Rheumatoid Arthritis Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid… (2009) · Cochrane | no estimate extracted | 1 study · 56 participants | Moderate |
Abatacept (2 and 10mg/kg) + DMARDs/biologic vs placebo + DMARDs/biologic ACR 50% improvement · patients with rheumatoid arthritis Abatacept for rheumatoid arthritis (2009) · Cochrane | RR 2.21 [1.73, 2.82] | 3 studies · 993 participants | Moderate |
Abatacept (2 and 10mg/kg) + DMARDs/biologic vs placebo + DMARDs/biologic Pain measured at end of study on a 100 mm visual analog scale. Scale from: 0 (better) to 100 (worse). · patients with rheumatoid arthritis Abatacept for rheumatoid arthritis (2009) · Cochrane | no estimate extracted | 1 study · 1425 participants | Moderate |
Abatacept (2 and 10mg/kg) + DMARDs/biologic vs placebo + DMARDs/biologic Improvement in physical function (HAQ: greater than 0.3 increase from baseline, 0‐3 scale) · patients with rheumatoid arthritis Abatacept for rheumatoid arthritis (2009) · Cochrane | RR 1.62 [1.35, 1.95] | 1 study · 638 participants | Moderate |
Abatacept (2 and 10mg/kg) + DMARDs/biologic vs placebo + DMARDs/biologic Achievement of low disease activity state (DAS 28 less than 3.2, scale 0‐10) · patients with rheumatoid arthritis Abatacept for rheumatoid arthritis (2009) · Cochrane | RR 4.33 [2.84, 6.59] | 1 study · 638 participants | Moderate |
Abatacept (2 and 10mg/kg) + DMARDs/biologic vs placebo + DMARDs/biologic Total serious adverse events · patients with rheumatoid arthritis Abatacept for rheumatoid arthritis (2009) · Cochrane | RR 1.05 [0.87, 1.28] | 6 studies · 3151 participants | Moderate |
Abatacept (2 and 10mg/kg) + DMARDs/biologic vs placebo + DMARDs/biologic Change in radiographic progression measured by Genant‐modifed Sharp erosion score (increase in score means more joint damage). Scale from: 0 to 145. · patients with rheumatoid arthritis Abatacept for rheumatoid arthritis (2009) · Cochrane | no estimate extracted | 1 study · 586 participants | Moderate |
Abatacept (2 and 10mg/kg) + DMARDs/biologic vs placebo + DMARDs/biologic Long‐term serious adverse events · patients with rheumatoid arthritis Abatacept for rheumatoid arthritis (2009) · Cochrane | no estimate extracted | 2 studies · 950 participants | Low |
Intervention NR Pain Various validated pain scales · Patients with osteoarthritis of the knee or hip S‐Adenosylmethionine for osteoarthritis of the knee or hip (2009) · Cochrane | no estimate extracted | 2 studies · 533 participants | Moderate |
Intervention NR Function Various validated function scales · Patients with osteoarthritis of the knee or hip S‐Adenosylmethionine for osteoarthritis of the knee or hip (2009) · Cochrane | SMD 0.02 | 3 studies · 542 participants | Low |
Intervention NR Number of patients experiencing any adverse event · Patients with osteoarthritis of the knee or hip S‐Adenosylmethionine for osteoarthritis of the knee or hip (2009) · Cochrane | RR 1.27 [0.94, 1.71] | 4 studies · 632 participants | Moderate |
Intervention NR Number of patients who withdrew because of adverse events · Patients with osteoarthritis of the knee or hip S‐Adenosylmethionine for osteoarthritis of the knee or hip (2009) · Cochrane | RR 0.94 [0.48, 1.86] | 4 studies · 656 participants | Moderate |
Intervention NR Number of patients experiencing any serious adverse event Median · Patients with osteoarthritis of the knee or hip S‐Adenosylmethionine for osteoarthritis of the knee or hip (2009) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Intervention NR Pain based on WOMAC pain scale Scale from: 0 (no pain) to 20 (worst pain). ( · patients with treating osteoarthritis Glucosamine therapy for treating osteoarthritis (2005) · Cochrane | no estimate extracted | 11 studies · 2173 participants | Moderate |
Intervention NR WOMAC Function Subscale Scale from: 0 to 68. ( · patients with treating osteoarthritis Glucosamine therapy for treating osteoarthritis (2005) · Cochrane | no estimate extracted | 9 studies · 2017 participants | High |
Intervention NR Physician Global Assessment 100 mm visual analogue scale. Scale from: 0 to 100. ( · patients with treating osteoarthritis Glucosamine therapy for treating osteoarthritis (2005) · Cochrane | no estimate extracted | 1 study · 630 participants | Moderate |
Intervention NR Patient Global Assessment (patients rated whether they were better at the end of trial than at the start of the trial) ( · patients with treating osteoarthritis Glucosamine therapy for treating osteoarthritis (2005) · Cochrane | RR 1.21 [0.8, 1.82] | 1 study · 118 participants | Moderate |
Intervention NR Minimum Joint Space Width mm ( · patients with treating osteoarthritis Glucosamine therapy for treating osteoarthritis (2005) · Cochrane | no estimate extracted | 2 studies · 414 participants | High |
Intervention NR Toxicity (Number of Patients Reporting Adverse Events) · patients with treating osteoarthritis Glucosamine therapy for treating osteoarthritis (2005) · Cochrane | RR 0.99 [0.91, 1.07] | 9 studies · 1640 participants | High |
Intervention NR Toxicity (Number of Withdrawals due to Adverse Events) · patients with treating osteoarthritis Glucosamine therapy for treating osteoarthritis (2005) · Cochrane | RR 0.76 [0.54, 1.07] | 12 studies · 2435 participants | Moderate |
Intervention NR Pain based on WOMAC scale Scale from: 0 (no pain) to 20 (worst pain). ( · patients with treating osteoarthritis Glucosamine therapy for treating osteoarthritis (2005) · Cochrane | no estimate extracted | 8 studies · 940 participants | Low |
Intervention NR WOMAC Function Subscale Scale from: 0 to 68. ( · patients with treating osteoarthritis Glucosamine therapy for treating osteoarthritis (2005) · Cochrane | no estimate extracted | 3 studies · 624 participants | High |
Summary of findings: leflunomide vs placebo, 6 months For outcome · adult patients with rheumatoid arthritis Leflunomide for the treatment of rheumatoid arthritis (2002) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: leflunomide + methotrexate vs methotrexate, 6 months Change in pain (0‐100 mm VAS) · adult patients with rheumatoid arthritis Leflunomide for the treatment of rheumatoid arthritis (2002) · Cochrane | no estimate extracted | 1 study · 263 participants | High |
Summary of findings: leflunomide + methotrexate vs methotrexate, 6 months Withdrawals due to adverse events (6 months) · adult patients with rheumatoid arthritis Leflunomide for the treatment of rheumatoid arthritis (2002) · Cochrane | no estimate extracted | 1 study · 263 participants | Moderate |
Summary of findings: leflunomide vs placebo, 6 months ACR 50 response at 6 months · adult patients with rheumatoid arthritis Leflunomide for the treatment of rheumatoid arthritis (2002) · Cochrane | RR 2.32 [1.32, 4.05] | 1 study · 221 participants | High |
Summary of findings: leflunomide vs placebo, 6 months HAQ change (0‐3 scale) · adult patients with rheumatoid arthritis Leflunomide for the treatment of rheumatoid arthritis (2002) · Cochrane | no estimate extracted | 3 studies · 679 participants | High |