Cochrane · systematic review · CD007321
S‐Adenosylmethionine for osteoarthritis of the knee or hip
Rutjes, AWS, Nüesch, E, Reichenbach, S, et al. · Cochrane Database of Systematic Reviews · 2009 · Cochrane Library
MusculoskeletalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 20%Very low 0 · 0%Low 1 · 20%Moderate 3 · 60%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: Patients with osteoarthritis of the knee or hip
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain Various validated pain scales | no estimate extracted | 2 studies · 533 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Function Various validated function scales | SMD 0.02 | 3 studies · 542 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Number of patients experiencing any adverse event | RR 1.27 [0.94, 1.71] | 4 studies · 632 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Number of patients who withdrew because of adverse events | RR 0.94 [0.48, 1.86] | 4 studies · 656 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Number of patients experiencing any serious adverse event Median | no estimate extracted | 0 studies · 0 participants | Ungraded |