Cochrane · systematic review · CD002946
Glucosamine therapy for treating osteoarthritis
Towheed, T, Maxwell, L, Anastassiades, TP, et al. · Cochrane Database of Systematic Reviews · 2005 · Cochrane Library
MusculoskeletalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
9
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 11.1%Moderate 4 · 44.4%High 4 · 44.4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings (adequate allocation concealment)
Population: patients with treating osteoarthritis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain based on WOMAC pain scale Scale from: 0 (no pain) to 20 (worst pain). ( | no estimate extracted | 11 studies · 2173 participants | Moderate Downgraded: inconsistency |
WOMAC Function Subscale Scale from: 0 to 68. ( | no estimate extracted | 9 studies · 2017 participants | High |
Physician Global Assessment 100 mm visual analogue scale. Scale from: 0 to 100. ( | no estimate extracted | 1 study · 630 participants | Moderate Downgraded: inconsistency |
Patient Global Assessment (patients rated whether they were better at the end of trial than at the start of the trial) ( | RR 1.21 [0.8, 1.82] | 1 study · 118 participants | Moderate Downgraded: imprecision, inconsistency |
Minimum Joint Space Width mm ( | no estimate extracted | 2 studies · 414 participants | High |
Toxicity (Number of Patients Reporting Adverse Events) | RR 0.99 [0.91, 1.07] | 9 studies · 1640 participants | High |
Toxicity (Number of Withdrawals due to Adverse Events) | RR 0.76 [0.54, 1.07] | 12 studies · 2435 participants | Moderate Downgraded: imprecision, inconsistency |
Summary of findings (Rotta preparation)
Population: patients with treating osteoarthritis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain based on WOMAC scale Scale from: 0 (no pain) to 20 (worst pain). ( | no estimate extracted | 8 studies · 940 participants | Low Downgraded: inconsistency |
WOMAC Function Subscale Scale from: 0 to 68. ( | no estimate extracted | 3 studies · 624 participants | High |