Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,126 questions · 1,225 findings · 111 reviews

No studies found 235 · 19.2%GRADE not reported 260 · 21.2%Very low 207 · 16.9%Low 271 · 22.1%Moderate 177 · 14.4%High 75 · 6.1%

Rice fortified with iron alone or in combination with other micronutrients vs unfortified rice (no micronutrients added)

Vitamin A deficiency · general population of all age groups (including pregnant women) from any country, over two years of age

Rice fortified with iron alone or in combination with other… showed no clear difference in vitamin A deficiency (as defined by the study authors) compared with unfortified rice (no micronutrients added) (low certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality in trials using vitamin D3 (cholecalciferol) ( · adults

The intervention probably leads to lower all‐cause mortality in trials using vitamin D3 (cholecalciferol) ( (moderate certainty).

1 finding from 1 review

Intervention not reported

Cardiovascular mortality in trials using vitamin D3 (cholecalciferol) ( · adults

The intervention showed no clear difference in cardiovascular mortality in trials using vitamin D3… (low certainty).

1 finding from 1 review

Intervention not reported

Cancer mortality in trials using vitamin D3 (cholecalciferol) ( · adults

The intervention probably leads to lower cancer mortality in trials using vitamin D3 (cholecalciferol) ( (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events: nephrolithiasis in trials using vitamin D3 combined with calcium ( · adults

The intervention probably leads to higher adverse events: nephrolithiasis in trials using vitamin D3 combined… (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events: hypercalcaemia in trials using the active forms of vitamin D (alfacalcidol and calcitriol) ( · adults

The intervention may leads to higher adverse events: hypercalcaemia in trials using the active forms of… (low certainty).

1 finding from 1 review

Pyridoxal 5 phosphate (vitamin B6) vs placebo

Clinical efficacy ‐ improvement (> 40%) in ESRS scores from baseline ESRS1 · patients with antipsychotic‐induced tardive dyskinesia

Pyridoxal 5 phosphate (vitamin B6) may leads to higher clinical efficacy ‐ improvement (> 40%) in ESRS scores from baseline… compared with placebo (low certainty).

1 finding from 1 review

Pyridoxal 5 phosphate (vitamin B6) vs placebo

Global: Other adverse effects than tardive dyskinesia Self‐report by participants · patients with antipsychotic‐induced tardive dyskinesia

Pyridoxal 5 phosphate (vitamin B6) showed no clear difference in global: Other adverse effects than tardive dyskinesia Self‐report by… compared with placebo (low certainty).

1 finding from 1 review

Pyridoxal 5 phosphate (vitamin B6) vs placebo

Tardive dyskinesia: Deterioration of symptoms · patients with antipsychotic‐induced tardive dyskinesia

Pyridoxal 5 phosphate (vitamin B6) showed no clear difference in tardive dyskinesia: Deterioration in tardive dyskinesia symptoms ESRS1 compared with placebo (low certainty).

1 finding from 1 review