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Evidence found and GRADE certainty

2,973 questions · 3,072 findings · 410 reviews · Headline outcomes only

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No studies found 559 · 18.2%GRADE not reported 143 · 4.7%Very low 654 · 21.3%Low 833 · 27.1%Moderate 683 · 22.2%High 200 · 6.5%

Summary of findings. Below‐elbow vs above‐elbow cast

'Treatment failure': secondary procedures such as remanipulation for early loss of position (only data for this used here); and change in treatment ( · children with either displaced distal radius fracture with intact or displaced ulna fracture (both‐bone fracture), or minimally displaced…

It is very uncertain whether summary of findings. Below‐elbow changes 'Treatment failure': secondary procedures such as remanipulation for… compared with above‐elbow cast (very low certainty).

1 finding from 1 review

Summary of findings. Surgery (percutaneous wire fixation) vs not surgery (cast only)

'Treatment failure': various secondary procedures such as remanipulation for early loss of position; early or more complex wire removal ( · children with displaced distal radius fracture with intact or involved or displaced ulna fracture (both‐bone fracture)

It is very uncertain whether summary of findings. Surgery (percutaneous wire fixation) changes 'Treatment failure': various secondary procedures such as… compared with not surgery (cast only) (very low certainty).

1 finding from 1 review

Low‐molecular‐weight heparins or heparinoids vs unfractionated heparin

Pulmonary embolism · acute ischaemic stroke

Low‐molecular‐weight heparins or heparinoids showed no clear difference in pulmonary embolism during treatment period (range 6 days to 16 days) compared with unfractionated heparin (low certainty).

1 finding from 1 review

Inhaled NO vs control

Death or bronchopulmonary dysplasia · respiratory failure in preterm infants

Inhaled NO showed no clear difference in death or bronchopulmonary dysplasia at 36 weeks ‐ Studies with entry… compared with control (high certainty).

2 findings from 1 review

Inhaled NO vs control

Death or bronchopulmonary dysplasia at 36 weeks PMA · respiratory failure in preterm infants

Inhaled NO showed no clear difference in death or bronchopulmonary dysplasia at 36 weeks ‐ Studies with entry… compared with control (high certainty).

1 finding from 1 review

Intervention not reported

Leukopenia** grade 3 or 4 (safety population) · women with metastatic breast cancer

The intervention probably leads to higher leukopenia** grade 3 or 4 (safety population) (moderate certainty).

1 finding from 1 review

Intervention not reported

Nausea/vomiting* grade 3 or 4 (safety population) by type of platinum agent in platinum regimen · women with metastatic breast cancer

The intervention probably leads to lower nausea/vomiting* grade 3 or 4 (safety population) by type of… (moderate certainty).

1 finding from 1 review

Intervention not reported

Anaemia grade 3 or 4 (safety population) by type of platinum agent in platinum regimen · women with metastatic breast cancer

The intervention leads to higher anaemia grade 3 or 4 (safety population) by type of platinum agent… (high certainty).

1 finding from 1 review

Intervention not reported

Hair loss grade 3 or 4 (safety population) · women with metastatic breast cancer

The intervention leads to higher hair loss grade 3 or 4 (safety population) (high certainty).

1 finding from 1 review

Low molecular weight heparin vs placebo or no prophylaxis

Pulmonary embolism · prevention of venous thromboembolism in patients with lower‐limb immobilization

Low molecular weight heparin showed no clear difference in pulmonary embolism compared with no prophylaxis or placebo (low certainty).

1 finding from 1 review