Cochrane · systematic review · CD000119
Low‐molecular‐weight heparins or heparinoids versus standard unfractionated heparin for acute ischaemic stroke
Sandercock, PAG, Leong, TS · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
StrokeAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 100%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Low‐molecular‐weight heparins or heparinoids compared with unfractionated heparin for acute ischaemic stroke
Population: acute ischaemic stroke
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death from all causes during treatment (range 6 days to 16 days) Low‐molecular‐weight heparins or heparinoids vs unfractionated heparin | OR 1.06 [0.78, 1.46] | 8 studies · 3102 participants | Low Downgraded: risk of bias, imprecision |
Death from all causes during Low‐molecular‐weight heparins or heparinoids vs unfractionated heparin | OR 0.98 [0.79, 1.23] | 8 studies · 3102 participants | Low Downgraded: risk of bias, imprecision |
Deep vein thrombosis during treatment period (range 6 days to 16 days) Low‐molecular‐weight heparins or heparinoids vs unfractionated heparin | OR 0.55 [0.44, 0.7] | 7 studies · 2585 participants | Low Downgraded: risk of bias, imprecision |
Pulmonary embolism during treatment period (range 6 days to 16 days) Low‐molecular‐weight heparins or heparinoids vs unfractionated heparin | OR 0.57 [0.23, 1.41] | 6 studies · 1250 participants | Low Downgraded: risk of bias, imprecision |
Symptomatic intracranial haemorrhage/haemorrhagic transformation of the cerebral infarct during treatment period (range 6 days to 16 days)⁹ Low‐molecular‐weight heparins or heparinoids vs unfractionated heparin | OR 0.73 [0.35, 1.54] | 8 studies · 3102 participants | Low Downgraded: risk of bias, imprecision |