What do systematic reviews say?

Health‐related quality of life Assessed by: SeiQoL‐DW (higher scores mean better quality of life) · adults with multiple sclerosis Interventions: immunosuppressive and immunomodulatory drugs Comparator: placebo Outcome: withdrawals due to…

Self‐reported pain relief ‐ NPSI: ranges from 0 to 100. Higher scores are indicative of neuropathic pain. · adults and children with sickle cell disease experiencing neuropathic pain

Self‐reported pain relief ‐ S‐LANSS: Possible total scores range from 0 to 24, and a score of 12 or higher is indicative of neuropathic pain. · adults and children with sickle cell disease experiencing neuropathic pain

Participant global assessment of success Not measured · adult participants with patellar tendinopathy

Self‐efficacy · older patients with multi‐morbidity

Depressive symptoms · people with dementia

Neuropsychiatric symptoms · people with dementia

Health‐related quality of life measured using QUALID (12–45, higher score indicates poorer quality of life) · people with dementia

Social functioning measured using MOSES, Withdrawn Behaviour subscale (8‐ 32, higher score indicates more severe withdrawn behaviour) · people with dementia

Behaviour · people with dementia

Agitation and irritability · people with dementia

Health‐related quality of life measured using QUALID (12–45, higher score indicates poorer quality of life) · people with dementia

ADL outcome · people with dementia

Physical functioning: self‐care ability measured using MOSES Self‐Care Functioning subscale (8–32, higher score indicates poorer function) · people with dementia

Adverse effects: astigmatism · people with recurrent corneal erosion syndrome without other corneal basement membrane dystrophy

Reading acuity · adults with low vision

Mean change from baseline in quality of life score (NEI VFQ‐25 instrument) · adults with low vision (people with AMD)

Hand function ‐ short term (less than 3 months) Grip function test scale of 0 to 80 points (higher score indicates better grip function) · rheumatoid arthritis of the hand

Hand function ‐ long term (12 months and beyond) Overall hand function subscale of the Michigan Hand Questionnaire, 0 to 100 (higher scores mean better hand function) · rheumatoid arthritis of the hand

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · rheumatoid arthritis of the hand