Cochrane · systematic review · CD012943
Interventions for treating neuropathic pain in people with sickle cell disease
Asnani, MR, Francis, DK, Brandow, AM, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Cystic Fibrosis and Genetic DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
4
No studies
3
Included studies
NR
No studies 3 · 42.9%Ungraded 0 · 0%Very low 4 · 57.1%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings ‐ Pharmacological intervention (pregabalin) versus placebo for treating neuropathic pain in people with sickle cell disease
Population: adults and children with sickle cell disease experiencing neuropathic pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Self‐reported pain relief ‐ NPSI: ranges from 0 to 100. Higher scores are indicative of neuropathic pain. Summary of findings ‐ Pharmacological intervention (pregabalin) vs placebo | no estimate extracted | 1 study · 16 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Self‐reported pain relief ‐ S‐LANSS: Possible total scores range from 0 to 24, and a score of 12 or higher is indicative of neuropathic pain. Summary of findings ‐ Pharmacological intervention (pregabalin) vs placebo | no estimate extracted | 1 study · 16 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
PGIC Summary of findings ‐ Pharmacological intervention (pregabalin) vs placebo | no estimate extracted | NR | No studies |
Time to improvement of symptoms Summary of findings ‐ Pharmacological intervention (pregabalin) vs placebo | no estimate extracted | NR | No studies |
Change in QoL Summary of findings ‐ Pharmacological intervention (pregabalin) vs placebo | no estimate extracted | 1 study · 16 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Changes in sleep quality as measured by sleep questionnaires Summary of findings ‐ Pharmacological intervention (pregabalin) vs placebo | no estimate extracted | NR | No studies |
Treatment‐related adverse effects Summary of findings ‐ Pharmacological intervention (pregabalin) vs placebo | RR 1.33 | 1 study · 22 participants | Very low Downgraded: risk of bias, imprecision, indirectness |