Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

380 questions · 393 findings · 51 reviews

No studies found 96 · 24.4%GRADE not reported 45 · 11.5%Very low 64 · 16.3%Low 77 · 19.6%Moderate 63 · 16%High 48 · 12.2%

Annual chest x‐ray screening vs usual care (no regular screening)

Mortality: lung cancer · Patients with lung cancer

Annual chest x‐ray screening showed no clear difference in lung cancer mortality at 6 years of compared with usual care (no regular screening) (high certainty).

2 findings from 1 review

Annual chest x‐ray screening vs usual care (no regular screening)

Deaths from all causes (excluding deaths from PLCO cancers) · Patients with lung cancer

Annual chest x‐ray screening showed no clear difference in deaths from all causes (excluding deaths from PLCO cancers) compared with usual care (no regular screening) (high certainty).

1 finding from 1 review

Screening for domestic violence vs Different screening tool

Proportion of victims of domestic violence detected by self report · Adults (16 years of age and older) who present to any healthcare setting with dental or facial injury

The review found no eligible studies for this question.

1 finding from 1 review

Screening for domestic violence vs No screening

Proportion of victims of domestic violence detected by self report · Adults (16 years of age and older) who present to any healthcare setting with dental or facial injury

The review found no eligible studies for this question.

1 finding from 1 review

Lower genital tract infection screening vs No screening

Preterm low birthweight (below or equal 2500 g) · pregnant women presenting for routine prenatal care

Lower genital tract infection screening probably leads to lower preterm low birthweight (below or equal 2500 g) compared with no screening (moderate certainty).

1 finding from 1 review

Lower genital tract infection screening vs No screening

Preterm very low birthweight (below or equal 1500 g) · pregnant women presenting for routine prenatal care

Lower genital tract infection screening probably leads to lower preterm very low birthweight (below or equal 1500 g) compared with no screening (moderate certainty).

1 finding from 1 review

Low‐dose computed tomography (LDCT) screening vs no LDCT screening

Mortality: lung cancer · healthy adults

Low‐dose computed tomography (LDCT) screening probably leads to lower lung cancer‐related mortality ‐ planned time points compared with no LDCT screening (moderate certainty).

1 finding from 1 review

Low‐dose computed tomography (LDCT) screening vs no LDCT screening

All‐cause mortality ‐ planned time points · healthy adults

Low‐dose computed tomography (LDCT) screening probably leads to lower all‐cause mortality ‐ planned time points compared with no LDCT screening (moderate certainty).

1 finding from 1 review

Low‐dose computed tomography (LDCT) screening vs no LDCT screening

Overdiagnosis Time point: ≥ 10 years from randomisation excluding CXR trials  · healthy adults

Low‐dose computed tomography (LDCT) screening showed no clear difference in overdiagnosis Time point: ≥ 10 years from randomisation excluding… compared with no LDCT screening (low certainty).

1 finding from 1 review

Low‐dose computed tomography (LDCT) screening vs no LDCT screening

Any death postsurgery Time point: 6 years to 9 years from randomisation · healthy adults

Low‐dose computed tomography (LDCT) screening showed no clear difference in any death postsurgery Time point: 6 years to 9 years from… compared with no LDCT screening (moderate certainty).

1 finding from 1 review

Low‐dose computed tomography (LDCT) screening vs no LDCT screening

Health‐related quality of life ‐ anxiety Time point: 10 months to 5 years from randomisation Measured by different scales · healthy adults

Low‐dose computed tomography (LDCT) screening showed no clear difference in health‐related quality of life ‐ anxiety Time point: 10 months to 5… compared with no LDCT screening (low certainty).

1 finding from 1 review

Systematic screening vs no/opportunistic screening

All‐cause mortality · general population including those at moderate to high risk of CVD, mean age between 30 and 75

Systematic screening showed no clear difference in all‐cause mortality compared with no/opportunistic screening (low certainty).

1 finding from 1 review

Systematic screening vs no/opportunistic screening

Total coronary heart disease · general population including those at moderate to high risk of CVD, mean age between 30 and 75

Systematic screening showed no clear difference in coronary heart disease (total) compared with no/opportunistic screening (low certainty).

1 finding from 1 review