Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

84 questions · 87 findings · 23 reviews · ENT

No studies found 21 · 24.1%GRADE not reported 0 · 0%Very low 29 · 33.3%Low 26 · 29.9%Moderate 11 · 12.6%High 0 · 0%

Antihistamines vs placebo

Adverse effects: 1. Sedation · patients with motion sickness

Antihistamines may leads to higher adverse effects: sedation Assessed by: adverse effect questionnaire… compared with placebo (low certainty).

1 finding from 1 review

Antihistamines vs placebo

Adverse effects: impaired cognition Assessed by: adverse effect questionnaire (presence or absence given numerical values) · patients with motion sickness

Antihistamines showed no clear difference in adverse effects: impaired cognition Assessed by: adverse effect… compared with placebo (low certainty).

1 finding from 1 review

Antihistamines vs placebo

Adverse effects ‐ Blurred vision No of patients with blurred vision · patients with motion sickness

Antihistamines showed no clear difference in adverse effects: blurred vision Assessed by: adverse effect… compared with placebo (low certainty).

1 finding from 1 review

Antimicrobial mouthwash and/or nasal spray (alone or in combination), any concentration, frequency or dosage vs No treatment or saline or water

COVID-19 viral content of aerosol (when present) · Patients with suspected or confirmed COVID-19 infection

The review found no eligible studies for this question.

1 finding from 1 review

Betahistine vs placebo

Depressive symptoms · patients with subjective idiopathic tinnitus

The review found no eligible studies for this question.

1 finding from 1 review
  • Betahistine for tinnitus 2018 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found