What do systematic reviews say?

Intervention not reported

The intervention probably leads to higher leukopaenia (safety population) (moderate certainty).

• Platinum‐containing regimens for triple‐negative metastatic breast cancer 2020 · Cochrane Headline outcomes only
  RR 1.09
  5 studies · 843 participants
  Moderate

Intervention not reported

The intervention showed no clear difference in hospital length of stay (patients recovering from orthopaedic surgery) (moderate certainty).

• Early discharge hospital at home 2017 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 411 participants
  Moderate

Zoledronate vs pamidronate or risedronate

• Bisphosphonates for Paget's disease of bone in adults 2017 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Bisphosphonates vs placebo

• Bisphosphonates for Paget's disease of bone in adults 2017 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

INO vs control group

INO showed no clear difference in mortality in paediatric population (subgroup) compared with control group (moderate certainty).

• Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) in children and adults 2016 · Cochrane Headline outcomes only
  RR 0.78 [0.51, 1.18]
  185 participants
  Moderate

Children: prednisolone vs dexamethasone

• Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 328 participants
  Very low

Fresh frozen plasma vs no plasma

• Fresh frozen plasma for cardiovascular surgery 2015 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 138 participants
  Low

Fresh frozen plasma vs no plasma

• Fresh frozen plasma for cardiovascular surgery 2015 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 110 participants
  Low

Intervention not reported

It is very uncertain whether the intervention changes severe thrombocytopaenia11 (very low certainty).

• Corticosteroids for dengue infection 2014 · Cochrane Headline outcomes only
  RR 1.51 [0.31, 7.28]
  1 study · 225 participants
  Very low

Intervention not reported

• Swimming training for asthma in children and adolescents aged 18 years and under 2013 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 50 participants
  Low

Intervention not reported

• Antibiotic prophylaxis for the prevention of methicillin‐resistant Staphylococcus aureus (MRSA) related complications… 2013 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 22 participants
  Very low

Intervention not reported

• Antibiotic prophylaxis for the prevention of methicillin‐resistant Staphylococcus aureus (MRSA) related complications… 2013 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 22 participants
  Very low

Slow passive expiration vs control

• Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 71 participants
  Low

Slow passive expiration vs control

Slow passive expiration showed no clear difference in change in the severity status of bronchiolitis Assessed using a… compared with control (low certainty).

• Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old 2023 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 434 participants
  Low

Slow passive expiration vs control

• Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old 2023 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 565 participants
  Very low

Forced expiration vs control

• Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old 2023 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 628 participants
  High

Forced expiration vs control

It is very uncertain whether forced expiration changes change in the severity status of bronchiolitis Assessed using a… compared with control (very low certainty).

• Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 132 participants
  Very low

Forced expiration vs control

Forced expiration leads to higher adverse events ( compared with control (high certainty).

• Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old 2023 · Cochrane Headline outcomes only
  RR 1
  2 studies · 599 participants
  High

Outpatient vs inpatients ‐ adults

Outpatients showed no clear difference in treatment failure compared with inpatients ‐ adults (moderate certainty).

• Outpatient treatment for people with cancer who develop a low‐risk febrile neutropaenic event 2019 · Cochrane Headline outcomes only
  RR 1.23 [0.82, 1.85]
  6 studies · 628 participants
  Moderate

Outpatient vs inpatients ‐ children

Outpatients showed no clear difference in adverse drug reactions compared with inpatients ‐ children (low certainty).

• Outpatient treatment for people with cancer who develop a low‐risk febrile neutropaenic event 2019 · Cochrane Headline outcomes only
  RR 1.9 [0.61, 5.98]
  2 studies · 156 participants
  Low