Cochrane · systematic review · CD007614
Fresh frozen plasma for cardiovascular surgery
Desborough, MJR, Sandu, R, Brunskill, SJ, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
HeartAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 16.7%Low 2 · 33.3%Moderate 3 · 50%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Fresh frozen plasma compared to no plasma for cardiovascular surgery
Population: Neonates, children and adults undergoing cardiovascular surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Short‐term mortality (up to 30 days) Fresh frozen plasma vs no plasma | no estimate extracted | 6 studies · 287 participants | Very low Downgraded: risk of bias |
Blood loss in first 24 hours (neonates and paediatric cases) Fresh frozen plasma vs no plasma | no estimate extracted | 4 studies · 138 participants | Low Downgraded: risk of bias, imprecision |
Red cell transfusion requirement in first 24 hours (neonates and paediatric cases) Fresh frozen plasma vs no plasma | no estimate extracted | 3 studies · 110 participants | Low Downgraded: risk of bias, imprecision |
Number of patients receiving a red cell transfusion Fresh frozen plasma vs no plasma | OR 2.57 [1.3, 5.08] | 4 studies · 222 participants | Moderate Downgraded: risk of bias, imprecision |
Measurement of prothrombin time within 2 hours of infusion Fresh frozen plasma vs no plasma | no estimate extracted | 5 studies · 210 participants | Moderate Downgraded: risk of bias |
Resource use: need for return to theatre Fresh frozen plasma vs no plasma | OR 0.81 [0.26, 2.57] | 7 studies · 398 participants | Moderate Downgraded: risk of bias |