Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

75 questions · 75 findings · 23 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

No studies found 10 · 13.3%GRADE not reported 0 · 0%Very low 16 · 21.3%Low 27 · 36%Moderate 17 · 22.7%High 5 · 6.7%

Intervention not reported

People with localised or systemic bacterial or fungal infections ‐ low‐dose granulocyte transfusions · people with neutropenia or neutrophil dysfunction

It is very uncertain whether the intervention changes people with localised or systemic bacterial or fungal infections ‐… (very low certainty).

1 finding from 1 review

Intervention not reported

People with localised or systemic bacterial or fungal infections ‐ Intermediate‐dose granulocyte transfusions · people with neutropenia or neutrophil dysfunction

The intervention may leads to lower people with localised or systemic bacterial or fungal infections ‐… (low certainty).

1 finding from 1 review

Benefits and harms of CSF plus antibiotics vs antibiotics alone

Time to recovery from fever (lower values signify better outcomes) · people with chemotherapy‐induced febrile neutropenia

Benefits and harms of CSF plus antibiotics showed no clear difference in time to recovery from fever (lower values signify better outcomes) compared with antibiotics alone (low certainty).

1 finding from 1 review

Benefits and harms of CSF plus antibiotics vs antibiotics alone

Time to withdrawal from ATB (lower values signify better outcomes) · people with chemotherapy‐induced febrile neutropenia

Benefits and harms of CSF plus antibiotics showed no clear difference in time to withdrawal from ATB (lower values signify better outcomes) compared with antibiotics alone (low certainty).

1 finding from 1 review

beta‐lactam monotherapy vs beta‐lactam (cloxacillin) plus aminoglycoside (gentamicin)

All cause mortality · people with cancer who have febrile neutropenia

beta‐lactam monotherapy showed no clear difference in all cause mortality compared with beta‐lactam‐aminoglycoside combination therapy (high certainty).

1 finding from 1 review

beta‐lactam monotherapy vs beta‐lactam (cloxacillin) plus aminoglycoside (gentamicin)

Any nephrotoxicity ‐ Ag dosing regimen (Copy) · people with cancer who have febrile neutropenia

beta‐lactam monotherapy leads to lower any nephrotoxicity ‐ Ag dosing regimen (Copy) compared with beta‐lactam‐aminoglycoside combination therapy (high certainty).

1 finding from 1 review

beta‐lactam monotherapy vs beta‐lactam (cloxacillin) plus aminoglycoside (gentamicin)

Clinical failure—same beta lactam Antibiotic modifications · people with cancer who have febrile neutropenia

beta‐lactam monotherapy probably leads to higher treatment failure ‐ same beta‐lactam compared with beta‐lactam‐aminoglycoside combination therapy (moderate certainty).

1 finding from 1 review