Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

68 questions · 68 findings · 19 reviews · Pregnancy and Childbirth

No studies found 11 · 16.2%GRADE not reported 6 · 8.8%Very low 21 · 30.9%Low 23 · 33.8%Moderate 6 · 8.8%High 1 · 1.5%

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Maternal iron‐deficiency anaemia at term (Hb less than 110 g/L and at least 1 additional laboratory indicators at 37 weeks' gestation or more) · Women receiving supplements in pregnancy

It is very uncertain whether any intermittent iron regimen (with or without other vitamins and… changes maternal iron‐deficiency anaemia at term (Hb less than 110 g/L and… compared with daily regimen (with same vitamins and minerals)‐maternal outcomes (very low certainty).

1 finding from 1 review

Home (point‐of‐use) fortification of foods with multiple micronutrient powders vs iron folic acid (IFA)

Maternal iron deficiency at term or near term (as defined by authors of the trials, based on any indicator of iron status at 34 weeks' gestation or more) · women during pregnancy
1 finding from 1 review

Home (point‐of‐use) fortification of foods with multiple micronutrient powders vs multiple micronutrients (MMN)

Maternal iron deficiency at term or near term (as defined by authors of the trials, based on any indicator of iron status at 34 weeks' gestation or more) · women during pregnancy
1 finding from 1 review

Nitrofurantoin and close surveillance vs close surveillance alone

Recurrent pyelonephritis · pregnant women with a history of one or more UTI before or during pregnancy

It is very uncertain whether nitrofurantoin and close surveillance changes recurrent pyelonephritis compared with close surveillance alone (very low certainty).

1 finding from 1 review

Nitrofurantoin and close surveillance vs close surveillance alone

Recurrent UTI (cystitis) · pregnant women with a history of one or more UTI before or during pregnancy

It is very uncertain whether nitrofurantoin and close surveillance changes recurrent UTI (cystitis) compared with close surveillance alone (very low certainty).

1 finding from 1 review

Nitrofurantoin and close surveillance vs close surveillance alone

Preterm birth · pregnant women with a history of one or more UTI before or during pregnancy

It is very uncertain whether nitrofurantoin and close surveillance changes preterm birth (< 37 weeks) compared with close surveillance alone (very low certainty).

1 finding from 1 review

Nitrofurantoin and close surveillance vs close surveillance alone

Birthweight < 2500 (g) · pregnant women with a history of one or more UTI before or during pregnancy

It is very uncertain whether nitrofurantoin and close surveillance changes birthweight < 2500 (g) compared with close surveillance alone (very low certainty).

1 finding from 1 review

Nitrofurantoin and close surveillance vs close surveillance alone

Apgar score less than 7 at 5 minutes · pregnant women with a history of one or more UTI before or during pregnancy

It is very uncertain whether nitrofurantoin and close surveillance changes five‐minute Apgar score < seven compared with close surveillance alone (very low certainty).

1 finding from 1 review

Nitrofurantoin and close surveillance vs close surveillance alone

Miscarriage · pregnant women with a history of one or more UTI before or during pregnancy

It is very uncertain whether nitrofurantoin and close surveillance changes miscarriages compared with close surveillance alone (very low certainty).

1 finding from 1 review

Antibiotics vs placebo

Mortality and morbidity prior to discharge (Neonatal intensive care admissions) · Women with meconium‐stained amniotic fluid in labour, gestational age more than 24 weeks

Antibiotic showed no clear difference in mortality and morbidity prior to discharge (Neonatal intensive care… compared with placebo (low certainty).

1 finding from 1 review