Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · children with acute postoperative pain
The review found no eligible studies for this question.
2 findings from 1 review
no estimate extracted
Studies not reported
No studies found
no estimate extracted
Studies not reported
No studies found
Adverse events (reported in the first 7 days after the procedure) · children with acute postoperative pain
Ibuprofen probably leads to lower adverse events (reported in the first 7 days after the procedure) compared with morphine (moderate certainty).
1 finding from 1 review
Serious adverse events, defined as any medical event at any dose that results in death, is life‐threatening, requires hospitalisation (or prolongation of existing hospitalisation) or results in permanent damage or disability (FDA 2016) · children with acute postoperative pain
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Constipation · adults with cancer‐related pain
It is very uncertain whether CR oxycodone changes constipation ‐ only English language studies (Event rate during… compared with CR morphine (very low certainty).
2 findings from 1 review
Drowsiness/somnolence (Event rate during treatment, length of treatment varied across trials) · adults with cancer‐related pain
CR oxycodone showed no clear difference in drowsiness/somnolence (Event rate during treatment, length of… compared with CR morphine (low certainty).
1 finding from 1 review
Nausea · adults with cancer‐related pain
CR oxycodone showed no clear difference in nausea (Event rate during treatment, length of treatment varied… compared with CR morphine (low certainty).
1 finding from 1 review
Vomiting · adults with cancer‐related pain
It is very uncertain whether CR oxycodone changes vomiting (Event rate during treatment, length of treatment varied… compared with CR morphine (very low certainty).
1 finding from 1 review
Quality of life · adults with cancer‐related pain
It is very uncertain whether CR oxycodone changes quality of life compared with CR morphine (very low certainty).
1 finding from 1 review
Participant preference · adults with cancer‐related pain
1 finding from 1 review
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · adults with cancer‐related pain
CR oxycodone may leads to higher pain intensity (various pain intensity scales; SMD) compared with CR morphine (low certainty).
1 finding from 1 review
Nausea · people with moderate to severe cancer pain
It is very uncertain whether hydromorphone changes specific adverse events – nausea compared with morphine (very low certainty).
1 finding from 1 review
Vomiting · people with moderate to severe cancer pain
It is very uncertain whether hydromorphone changes specific adverse events – vomiting compared with morphine (very low certainty).
1 finding from 1 review
Dizziness · people with moderate to severe cancer pain
It is very uncertain whether hydromorphone changes specific adverse events – dizziness compared with morphine (very low certainty).
1 finding from 1 review
Constipation · people with moderate to severe cancer pain
1 finding from 1 review
Quality of life · people with moderate to severe cancer pain
The review found no eligible studies for this question.
1 finding from 1 review
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · people with moderate to severe cancer pain
1 finding from 1 review
Relief of pain · people with moderate to severe cancer pain
It is very uncertain whether hydromorphone changes participant‐reported pain relief compared with morphine (very low certainty).
1 finding from 1 review
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · people with cancer pain
Methadone may leads to higher participant‐reported pain intensity compared with morphine (low certainty).
1 finding from 1 review
Adverse events: appetite, thirst, somnolence · people with cancer pain
1 finding from 1 review
At least 30% reduction in pain · people with cancer pain
1 finding from 1 review