Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

81 questions · 87 findings · 19 reviews · Pain, Palliative and Supportive Care

No studies found 3 · 3.4%GRADE not reported 1 · 1.1%Very low 31 · 35.6%Low 32 · 36.8%Moderate 17 · 19.5%High 3 · 3.4%

Psychological therapies vs controls

Responder rate (achievement of at least 50% reduction in migraine frequency) Higher numbers mean more people responded · adults with migraine

It is very uncertain whether psychological therapies changes responder rate (achievement of at least 50% reduction in migraine… compared with controls (very low certainty).

1 finding from 1 review

Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo

Participant‐reported sleep problems (scale: 0 to 28; higher scores indicate more sleep problems) · patients with fibromyalgia

Serotonin noradrenaline reuptake inhibitors showed no clear difference in self‐reported sleep problems (0‐100 scale) Higher scores indicate… compared with placebo (low certainty).

1 finding from 1 review

Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo

Self‐reported health‐related quality of life (0‐100 scale) Higher scores indicate higher burden of disease (lower quality of life) · patients with fibromyalgia

Serotonin noradrenaline reuptake inhibitors showed no clear difference in self‐reported health‐related quality of life (0‐100 scale) Higher… compared with placebo (low certainty).

1 finding from 1 review

Mirtazapine vs placebo

Participant‐reported sleep problems (scale: 0 to 28; higher scores indicate more sleep problems) · adults with fibromyalgia

Mirtazapine showed no clear difference in participant‐reported sleep problems (scale: 0 to 28; higher scores… compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

Health‐related quality of life (HRQOL), SD units: measured on FACIT‐Pal, TOI of FACT‐Hep, TOI of FACT‐L, FACT‐G, McGill Quality of Life, FACIT‐Sp. Higher scores indicate better HRQOL. · patients with advanced cancer
1 finding from 1 review

Intervention not reported

Depression, SD units: measured on CES‐D, HADS‐D, PHQ‐9. Higher scores indicate higher depressive symptom load. · patients with advanced cancer
1 finding from 1 review

Intervention not reported

Depression, natural units: measured on CES‐D (from 0 to 60). Higher scores indicate higher depressive symptom load · patients with advanced cancer
1 finding from 1 review

Intervention not reported

Symptom intensity, SD units: measured on ESAS, QUAL‐E Symptom Impact Subscale, SDS, RSC, LCS of FACT‐L, HCS of FACT‐Hep. Higher scores indicate higher symptom intensity. · patients with advanced cancer
1 finding from 1 review

Intervention not reported

Sleep problems (Scale 0 to 21; higher scores indicate more sleep problems) · adults with fibromyalgia
1 finding from 1 review

Intervention not reported

Pain end of treatment (0‐10 scale) Higher scores indicate higher pain levels · Patients with fibromyalgia
1 finding from 1 review

Intervention not reported

Negative mood end of treatment (0‐10 scale) Higher scores indicate higher negative mood levels · Patients with fibromyalgia
1 finding from 1 review

Intervention not reported

Disability end of treatment (0‐10 scale) Higher scores indicate disability levels · Patients with fibromyalgia
1 finding from 1 review

Intervention not reported

Total studies: 42 Total participants: 14,626 · people with chronic pain Interventions: desvenlafaxine high dose (≥ 50 mg); duloxetine low dose (< 60 mg), standard dose (60 mg), and high…

The intervention led to lower total studies: 42 Total participants: 14,626; GRADE not reported.

1 finding from 1 review