Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

87 questions · 87 findings · 6 reviews · Headline outcomes only

No studies found 7 · 8%GRADE not reported 0 · 0%Very low 15 · 17.2%Low 32 · 36.8%Moderate 31 · 35.6%High 2 · 2.3%

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants

HIV Transmission or Death at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP plus ZDV dual regimen administered to infants for 14… showed no clear difference in HIV Transmission or Death at 9 months among those whose HIV… compared with an extended NVP regimen administered to infants (moderate certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants

Infant Mortality at 24 months among those uninfected at birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP plus ZDV dual regimen administered to infants for 14… showed no clear difference in infant Mortality at 24 months among those uninfected at birth compared with an extended NVP regimen administered to infants (moderate certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants

HIV Transmission or Death at 24 months among those uninfected at birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP plus ZDV dual regimen administered to infants for 14… showed no clear difference in HIV Transmission or Death at 24 months among those uninfected at birth compared with an extended NVP regimen administered to infants (moderate certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants

Infants with Severe Adverse Events · Breastfeeding infants of HIV‐infected mothers

An extended NVP plus ZDV dual regimen administered to infants for 14… may leads to higher infants with any Severe Adverse Events compared with an extended NVP regimen administered to infants (low certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants

Infants with Probably Related Severe Adverse Events · Breastfeeding infants of HIV‐infected mothers

It is very uncertain whether an extended NVP plus ZDV dual regimen administered to infants for 14… changes infants with Probably Related Severe Adverse Events compared with an extended NVP regimen administered to infants (very low certainty).

1 finding from 1 review

An extended ZDV/3TC/LPV/r regimen administered to mothers vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

HIV transmission at 6 months among those whose diagnostic testing was negative at 6 weeks after birth · HIV‐infected mothers and their breastfeeding infants

An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in HIV transmission at 6 months among those whose diagnostic testing… compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (low certainty).

1 finding from 1 review

An extended ZDV/3TC/LPV/r regimen administered to mothers vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

HIV transmission at 12 months among those whose diagnostic testing was negative at 6 weeks after birth · HIV‐infected mothers and their breastfeeding infants

An extended ZDV/3TC/LPV/r regimen administered to mothers may leads to lower HIV transmission at 12 months among those whose diagnostic testing… compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (low certainty).

1 finding from 1 review

An extended ZDV/3TC/LPV/r regimen administered to mothers vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

Infant Mortality at 6 Months · HIV‐infected mothers and their breastfeeding infants

An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in infant Mortality at 6 months compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (low certainty).

1 finding from 1 review

An extended ZDV/3TC/LPV/r regimen administered to mothers vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

Infant Mortality at 12 months · HIV‐infected mothers and their breastfeeding infants

An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in infant Mortality at 12 months compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (low certainty).

1 finding from 1 review

An extended ZDV/3TC/LPV/r regimen administered to mothers vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

HIV transmission or Death at 6 months among those whose HIV diagnostic testing was negative at 6 weeks after birth · HIV‐infected mothers and their breastfeeding infants

An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in HIV transmission or Death at 6 months among those whose HIV… compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (low certainty).

1 finding from 1 review

An extended ZDV/3TC/LPV/r regimen administered to mothers vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

HIV transmission or death at 12 months among all infants whose HIV diagnostic testing was negative within 6 weeks of birth · HIV‐infected mothers and their breastfeeding infants

An extended ZDV/3TC/LPV/r regimen administered to mothers probably leads to lower HIV transmission or Death at 12 months among those whose HIV… compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (moderate certainty).

1 finding from 1 review

An extended ZDV/3TC/LPV/r regimen administered to mothers vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)

Maternal Grade 3/4 Severe Adverse Events · HIV‐infected mothers and their breastfeeding infants

It is very uncertain whether an extended ZDV/3TC/LPV/r regimen administered to mothers changes maternal Grade 3/4 Severe Adverse Events compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (very low certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 6 weeks vs sdNVP

HIV Transmission at 6 months among those whose HIV diagnostic testing was negative within 7 days of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 6 weeks showed no clear difference in HIV Transmission at 6 months among those whose HIV diagnostic… compared with sdNVP (moderate certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 6 weeks vs sdNVP

Infant Mortality at 6 months among those whose HIV diagnostic testing was negative within 7 days of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 6 weeks may leads to lower infant Mortality at 6 months among those whose HIV diagnostic… compared with sdNVP (low certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 6 weeks vs sdNVP

HIV Transmission or Death at 6 months among those whose HIV diagnostic testing was negative within 7 days of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 6 weeks probably leads to lower HIV Transmission or Death at 6 months among those whose HIV… compared with sdNVP (moderate certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 6 weeks vs sdNVP

Genotypic Resistance to NVP among Ugandan infants HIV‐infected at 6 weeks ViroSeq · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 6 weeks may leads to higher genotypic Resistance to NVP among Ugandan infants HIV‐infected at 6… compared with sdNVP (low certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 6 weeks vs sdNVP

Persistance of Genotypic Resistance to NVP at 6 months among Ugandan infants found to be resistant at 6 weeks ViroSeq · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 6 weeks may leads to higher persistance of Genotypic Resistance to NVP at 6 months among Ugandan… compared with sdNVP (low certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 6 weeks vs sdNVP

Genotypic Resistance to NVP among Indian infants HIV‐infected in utero or through peripartum/early‐breastfeeding transmission Standard Population Sequencing · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 6 weeks may leads to higher genotypic Resistance to NVP among Indian infants HIV‐infected in… compared with sdNVP (low certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 6 weeks vs sdNVP

Genotypic Resistance to NVP among Indian infants HIV‐infected through late breastfeeding Standard Population Sequencing · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 6 weeks showed no clear difference in genotypic Resistance to NVP among Indian infants HIV‐infected… compared with sdNVP (low certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 6 weeks vs sdNVP

HIV Transmission at 12 months among those whose HIV diagnostic testing was negative within 7 days of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 6 weeks showed no clear difference in HIV Transmission at 12 months among those whose HIV diagnostic… compared with sdNVP (moderate certainty).

1 finding from 1 review