An extended ZDV/3TC/LPV/r regimen administered to mothers vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP): Maternal Grade 3/4 Severe Adverse Events
- Population
- HIV‐infected mothers and their breastfeeding infants
- Intervention
- An extended ZDV/3TC/LPV/r regimen administered to mothers
- Comparison
- Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)
- Outcome
- Maternal Grade 3/4 Severe Adverse Events
It is very uncertain whether an extended ZDV/3TC/LPV/r regimen administered to mothers changes maternal Grade 3/4 Severe Adverse Events compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
An extended ZDV/3TC/LPV/r regimen administered to mothers vs short course ZDV (intrapartum ZDV/3TC/sdNVP) Maternal Grade 3/4 Severe Adverse Events · HIV‐infected mothers and their breastfeeding infants It is very uncertain whether an extended ZDV/3TC/LPV/r regimen administered to mothers changes maternal Grade 3/4 Severe Adverse Events compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (very low certainty). Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane Headline outcomes only | RR 1.19 [0.83, 1.7] | 1 study · 824 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antiretroviral interventions for preventing breast milk transmission of HIV 2014 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- An extended ZDV/3TC/LPV/r regimen administered to mothers vs an extended ZDV/3TC/ABC administered to mothers · HIV‐infected mothers and their breastfeeding infants · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.