An extended ZDV/3TC/LPV/r regimen administered to mothers vs Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP): HIV transmission at 6 months among those whose diagnostic testing was negative at 6 weeks after birth
- Population
- HIV‐infected mothers and their breastfeeding infants
- Intervention
- An extended ZDV/3TC/LPV/r regimen administered to mothers
- Comparison
- Short‐Course AZT (intrapartum AZT/3TC/sd‐NVP)
- Outcome
- HIV transmission at 6 months among those whose diagnostic testing was negative at 6 weeks after birth
An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in HIV transmission at 6 months among those whose diagnostic testing… compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
An extended ZDV/3TC/LPV/r regimen administered to mothers vs short course ZDV (intrapartum ZDV/3TC/sdNVP) HIV transmission at 6 months among those whose diagnostic testing was negative at 6 weeks after birth · HIV‐infected mothers and their breastfeeding infants An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in HIV transmission at 6 months among those whose diagnostic testing… compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (low certainty). Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane Headline outcomes only | HR 0.36 [0.13, 1.02] | 1 study · 597 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antiretroviral interventions for preventing breast milk transmission of HIV 2014 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.