Recurrent oral ulcerations (WHO clinical stage 2) · Children or adolescents
CLWH on ART had significantly higher prevalence of recurrent oral ulcerations than healthy controls (pooled OR 6.83, 95% CI 1.18 to 39.53).
1 finding from 1 review
Recurrent oral ulceration prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in recurrent oral ulceration between ART regimens (very low certainty).
1 finding from 1 review
Ulcerative stomatitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
Ulcerative stomatitis was significantly more prevalent in treatment-naive CLWH than in those on ART (very low certainty).
1 finding from 1 review
OR 0.03 [0.02, 0.07]
Studies not reported
Very low
Acute necrotizing ulcerative gingivitis/periodontitis (WHO clinical stage 3) · Children or adolescents
No eligible studies reported acute necrotizing ulcerative gingivitis/periodontitis.
1 finding from 1 review
Acute necrotising ulcerative periodontitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in acute necrotising ulcerative periodontitis between ART regimens (very low certainty).
1 finding from 1 review
Recurrent oral ulceration prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in recurrent oral ulceration between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 1.50 [0.72, 3.13]
Studies not reported
Very low
Oral ulcerations · Children and adolescents with juvenile idiopathic arthritis (JIA)
A single study reported more oral ulcerations in children with JIA (5/41) than without JIA (1/41); evidence is limited to one study (ungraded).
1 finding from 1 review
Enamel demineralization (DIAGNOdent score) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Adhesive precoated flash-free brackets showed no demineralization difference, with certainty not graded.
1 finding from 1 review
Intergroup evaluation showed that there were no statistically significant differences in demineralization measurements between all sides of the conventional and flash-free brackets at all the time intervals (p >0.05).
1 study · 30 participants
GRADE not reported
White spot lesions assessed by laser fluorescence (DIAGNOdent) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
Two studies found adhesive flash-free brackets did not clinically reduce enamel demineralization or white spot lesions versus conventional brackets, though they reduced pathogenic bacteria (ungraded).
1 finding from 1 review
DMFT/DMFS index (dental caries experience) · Patients with IBD (Crohn's disease and ulcerative colitis) and controls without IBD
Most included studies reported higher dental caries indices (DMF-t/DMF-s) in IBD patients (especially ulcerative colitis), but findings were inconsistent across studies and were not meta-analyzed or GRADE-rated.
1 finding from 1 review
Aesthetics · Adults (18 years or older) needing a three-unit fixed dental prosthesis (FDP)
The review found no eligible studies for this question.
1 finding from 1 review
Plaque · Adults (18 years or older) needing replacement of one premolar or incisor with a cantilevered fixed dental prosthesis
Metal-free cantilevered FDPs (feldspathic-veneered zirconia) showed no clear difference in plaque index (PI) compared with metal-ceramic cantilevered FDPs; GRADE not reported.
1 finding from 1 review
Cantilevered bridge failure · Adults (18 years or older) needing replacement of one premolar or incisor with a cantilevered fixed dental prosthesis
1 finding from 1 review
Gingival index (GI) · Adults (18 years or older) needing replacement of one premolar or incisor with a cantilevered fixed dental prosthesis
Metal-free cantilevered FDPs (feldspathic-veneered zirconia) showed no clear difference in gingival index (GI) compared with metal-ceramic cantilevered FDPs; GRADE not reported.
1 finding from 1 review
Cantilevered bridge complications · Adults (18 years or older) needing replacement of one premolar or incisor with a cantilevered fixed dental prosthesis
It is very uncertain whether metal-free cantilevered FDPs (feldspathic-veneered zirconia) changes cantilevered bridge complications compared with metal-ceramic cantilevered FDPs (very low certainty).
2 findings from 1 review
Bridge complications · Adults (18 years or older) needing a three-unit fixed dental prosthesis (FDP)
It is very uncertain whether metal-free FDPs (lithium disilicate) changes bridge complications compared with metal-ceramic FDPs (very low certainty).
1 finding from 1 review
Bridge failure · Adults (18 years or older) needing a three-unit fixed dental prosthesis (FDP)
It is very uncertain whether metal-free FDPs (lithium disilicate) changes bridge failure compared with metal-ceramic FDPs (very low certainty).
2 findings from 1 review
Periodontal/peri-implant status and occlusal wear (secondary outcomes) · Adults (18 years or older) needing a three-unit fixed dental prosthesis (FDP)
The review found no eligible studies for this question.
1 finding from 1 review
Aesthetics evaluated by the patient · Adults (18 years or older) needing replacement of one premolar or incisor with a cantilevered fixed dental prosthesis
It is very uncertain whether metal-free cantilevered FDPs (feldspathic-veneered zirconia) changes aesthetic evaluation (patient VAS) compared with metal-ceramic cantilevered FDPs (very low certainty).
1 finding from 1 review
Clinical failure (post dislodgement) · Participants with endodontically-treated permanent premolars restored with a carbon-fibre post (Category III)
Direct composite restoration (final restoration) showed no clear difference in clinical failure (post dislodgement) compared with full-coverage metal-ceramic crown; GRADE not reported.
1 finding from 1 review