Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

56 questions · 56 findings · 9 reviews

No studies found 16 · 28.6%GRADE not reported 8 · 14.3%Very low 25 · 44.6%Low 5 · 8.9%Moderate 2 · 3.6%High 0 · 0%

SSRIs or SNRIs vs amitriptyline

Participants who withdraw because of an adverse event or any other reason · patients for whom migraine preventive interventions are indicated

SSRIs or SNRIs showed no clear difference in withdrawn (for any reasons and due to adverse events) compared with amitriptyline (low certainty).

1 finding from 1 review

Intervention not reported

At least 50% reduction in pain or equivalent (substantial) · adults with fibromyalgia

It is very uncertain whether the intervention changes at least 50% reduction in pain or equivalent (substantial) (very low certainty).

1 finding from 1 review

Intervention not reported

At least 30% reduction in pain or equivalent (moderate) · adults with fibromyalgia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse event withdrawals · adults with fibromyalgia

It is very uncertain whether the intervention changes adverse event withdrawals (very low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events · adults with fibromyalgia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Death · adults with fibromyalgia

The review found no eligible studies for this question.

1 finding from 1 review