Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,271 questions · 1,326 findings · 329 reviews

No studies found 247 · 18.6%GRADE not reported 237 · 17.9%Very low 379 · 28.6%Low 285 · 21.5%Moderate 141 · 10.6%High 37 · 2.8%

Methotrexate vs placebo

Participants able to reduce corticosteroid or IVIg dose by more than 20% · people with CIDP

Methotrexate showed no clear difference in participants able to reduce corticosteroid or IVIg dose by more than… compared with placebo (moderate certainty).

1 finding from 1 review

Oral or topical or intraperitoneal antibiotics vs placebo/no treatment

Peritonitis · chronic peritoneal dialysis patients

Oral or topical or intraperitoneal antibiotics showed no clear difference in peritonitis (number of patients with one or more episodes) compared with placebo/no treatment (low certainty).

1 finding from 1 review

Any antifungal intervention for the treatment of oral candidiasis vs placebo/no treatment

Fungal peritonitis (number of patients with one or more episodes) · chronic peritoneal dialysis patients

Antifungal may leads to lower fungal peritonitis (number of patients with one or more episodes) compared with placebo/no treatment (low certainty).

1 finding from 1 review

Oral or topical or intraperitoneal antibiotics vs placebo/no treatment

Exit‐site/tunnel infection · chronic peritoneal dialysis patients

Oral or topical or intraperitoneal antibiotics showed no clear difference in exit‐site/tunnel infection (number of patients with one or more… compared with placebo/no treatment (low certainty).

1 finding from 1 review

Topical disinfectants vs standard care or other active treatment (antibiotic or other disinfectant)

Peritonitis · chronic peritoneal dialysis patients

Topical disinfectants showed no clear difference in peritonitis (number of patients with one or more episodes) compared with standard care or other active treatment (antibiotic or other… (low certainty).

1 finding from 1 review

Topical disinfectants vs standard care or other active treatment (antibiotic or other disinfectant)

Exit‐site/tunnel infection · chronic peritoneal dialysis patients

Topical disinfectants showed no clear difference in exit‐site/tunnel infection (number of patients with one or more… compared with standard care or other active treatment (antibiotic or other… (low certainty).

1 finding from 1 review

Tailored interventions based on sputum eosinophils vs tailored interventions based on clinical symptoms

Exacerbations · people with asthma

Tailored interventions based on sputum eosinophils probably leads to lower number of participants who had one or more exacerbations over the… compared with tailored interventions based on clinical symptoms (moderate certainty).

1 finding from 1 review

Intervention not reported

Number of participants who had one or more exacerbation of the study period · Adults from minority groups with doctor diagnosed asthma

It is very uncertain whether the intervention changes number of participants who had one or more exacerbation of the study… (very low certainty).

1 finding from 1 review