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Evidence found and GRADE certainty

2,087 questions · 2,360 findings · 390 reviews

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No studies found 224 · 9.5%GRADE not reported 603 · 25.6%Very low 555 · 23.5%Low 548 · 23.2%Moderate 312 · 13.2%High 118 · 5%

Early taxane‐based chemotherapy and androgen deprivation therapy (ADT) vs ADT only

Death (all causes)

Early taxane‐based chemotherapy and androgen deprivation therapy (ADT) probably leads to lower time to death due to any cause (absolute effect size estimates based… compared with ADT only (moderate certainty).

1 finding from 1 review

Early taxane‐based chemotherapy and androgen deprivation therapy (ADT) vs ADT only

Time to progression

Early taxane‐based chemotherapy and androgen deprivation therapy (ADT) probably leads to lower time to progression (absolute effect size estimates based on… compared with ADT only (moderate certainty).

1 finding from 1 review

Secondary alveolar bone grafting performed at one timing (e.g. early secondary grafting) vs Secondary alveolar bone grafting performed at a different / optimal timing (e.g. late secondary grafting)

Outcome not reported · Patients greater than 5 years of age with unilateral or bilateral cleft lip and/or palate involving the alveolar process (complete or…

The review found no eligible studies for this question.

1 finding from 1 review

Early treatment (two-phase: phase 1 in childhood, phase 2 in adolescence) with functional appliance vs Late treatment (one-phase in adolescence) with functional appliance

Self concept · Children (7 to 11 years) and adolescents (12 to 16 years) with prominent upper front teeth (Class II malocclusion)

Early treatment (two-phase: phase 1 in childhood, phase 2 in… showed no clear difference in self concept compared with late treatment (one-phase in adolescence) with functional appliance; GRADE not reported.

2 findings from 1 review

Early treatment (two-phase: phase 1 in childhood, phase 2 in adolescence) with functional appliance vs Late treatment (one-phase in adolescence) with functional appliance

Incidence of new incisal trauma · Children (7 to 11 years) and adolescents (12 to 16 years) with prominent upper front teeth (Class II malocclusion)

Early treatment (two-phase: phase 1 in childhood, phase 2 in… probably leads to lower incidence of new incisal trauma compared with late treatment (one-phase in adolescence) with functional appliance (moderate certainty).

1 finding from 1 review

Early treatment (two-phase: phase 1 in childhood, phase 2 in adolescence) with functional appliance vs Late treatment (one-phase in adolescence) with functional appliance

Final overjet · Children (7 to 11 years) and adolescents (12 to 16 years) with prominent upper front teeth (Class II malocclusion)

Early treatment (two-phase: phase 1 in childhood, phase 2 in… led to lower final overjet compared with late treatment (one-phase in adolescence) with functional appliance; GRADE not reported.

2 findings from 1 review

Early treatment (two-phase: phase 1 in childhood, phase 2 in adolescence) with functional appliance vs Late treatment (one-phase in adolescence) with functional appliance

Final ANB · Children (7 to 11 years) and adolescents (12 to 16 years) with prominent upper front teeth (Class II malocclusion)

Early treatment (two-phase: phase 1 in childhood, phase 2 in… led to lower final ANB compared with late treatment (one-phase in adolescence) with functional appliance; GRADE not reported.

2 findings from 1 review

Early treatment (two-phase: phase 1 in childhood, phase 2 in adolescence) with functional appliance vs Late treatment (one-phase in adolescence) with functional appliance

Incidence of incisal trauma · Children (7 to 11 years) and adolescents (12 to 16 years) with prominent upper front teeth (Class II malocclusion)

Early treatment (two-phase: phase 1 in childhood, phase 2 in… showed no clear difference in incidence of incisal trauma compared with late treatment (one-phase in adolescence) with functional appliance; GRADE not reported.

1 finding from 1 review

Early treatment (two-phase: phase 1 in childhood, phase 2 in adolescence) with functional appliance vs Late treatment (one-phase in adolescence) with functional appliance

PAR score · Children (7 to 11 years) and adolescents (12 to 16 years) with prominent upper front teeth (Class II malocclusion)

Early treatment (two-phase: phase 1 in childhood, phase 2 in… led to lower PAR score compared with late treatment (one-phase in adolescence) with functional appliance; GRADE not reported.

2 findings from 1 review

Zuclopenthixol dihydrochloride vs placebo

Leaving the study early · patients with schizophrenia

It is very uncertain whether zuclopenthixol dihydrochloride changes leaving the study early (any reason) compared with placebo (very low certainty).

2 findings from 2 reviews · compare the 2 reviews

Highest BMI category (overweight/obese) vs Lowest BMI category (normal weight/underweight)

Early childhood caries (ECC) · Children (approx. 4-18 years)

In the Region: Asian countries subgroup, the BMI (highest vs lowest)-childhood caries association was significant (OR 1.70, 95% CI 1.25 to 2.32; ungraded).

17 findings from 1 review
Show 14 more findings

High-frequency sugar consumption (three or more times daily) vs Low sugar intake (fewer than three times daily)

Early childhood caries experience (mean dmft) · Nigerian children with primary dentition (approximately 6 months to 5 years)

In primary dentition, high-frequency sugar consumption was associated with slightly higher, non-significant odds of caries (OR 1.13, 95% CI 0.23 to 5.44), with high heterogeneity (I2=83%; ungraded).

1 finding from 1 review