Cochrane · systematic review · CD012642
Higher versus lower sodium intake for preterm infants
Diller, N, Osborn, DA, Birch, P · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
11
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 10 · 47.6%Very low 6 · 28.6%Low 5 · 23.8%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Early (less than seven days following birth) higher versus lower sodium intake for preterm infants
Population: preterm or low birth weight infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality (latest time reported up to hospital discharge) Early (less than seven days following birth) higher vs lower sodium intake | RR 1.02 [0.38, 2.72] | 3 studies · 83 participants | Low Downgraded: imprecision |
Neurodevelopmental disability Early (less than seven days following birth) higher vs lower sodium intake | no estimate extracted | 0 studies · 0 participants | Ungraded |
Hyponatraemia (< 130 mmol/L) Early (less than seven days following birth) higher vs lower sodium intake | RR 0.68 [0.4, 1.13] | 3 studies · 83 participants | Low Downgraded: imprecision |
Hypernatraemia (≥ 150 mmol/L) Early (less than seven days following birth) higher vs lower sodium intake | RR 1.62 [1, 2.65] | 4 studies · 103 participants | Low Downgraded: imprecision |
Postnatal growth failure Early (less than seven days following birth) higher vs lower sodium intake | no estimate extracted | 0 studies · 0 participants | Ungraded |
Necrotising enterocolitis Early (less than seven days following birth) higher vs lower sodium intake | RR 4.6 [0.23, 90.84] | 1 study · 46 participants | Very low Downgraded: imprecision |
Chronic lung disease Early (less than seven days following birth) higher vs lower sodium intake | no estimate extracted | 0 studies · 0 participants | Ungraded |
Late (seven days or more following birth) higher versus lower sodium intake for preterm infants
Population: preterm or low birth weight infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality (latest time reported up to hospital discharge) Late (seven days or more following birth) higher vs lower sodium intake | RR 0.13 [0.01, 2.2] | 1 study · 49 participants | Very low Downgraded: risk of bias, imprecision |
Neurodevelopmental disability Late (seven days or more following birth) higher vs lower sodium intake | no estimate extracted | 0 studies · 0 participants | Ungraded |
Hyponatraemia (< 130 mmol/L) Late (seven days or more following birth) higher vs lower sodium intake | RR 0.13 [0.03, 0.5] | 2 studies · 69 participants | Low Downgraded: risk of bias |
Hypernatraemia (≥ 150 mmol/L) Late (seven days or more following birth) higher vs lower sodium intake | RR 7.88 [0.43, 144.81] | 2 studies · 69 participants | Very low Downgraded: risk of bias, imprecision |
Postnatal growth failure (weight < 10th percentile) Late (seven days or more following birth) higher vs lower sodium intake | RR 0.25 [0.09, 0.69] | 1 study · 29 participants | Low Downgraded: risk of bias, imprecision |
Necrotising enterocolitis Late (seven days or more following birth) higher vs lower sodium intake | RR 0.07 [0, 1.25] | 1 study · 49 participants | Very low Downgraded: risk of bias, imprecision |
Chronic lung disease Late (seven days or more following birth) higher vs lower sodium intake | RR 2.03 [0.8, 5.2] | 1 study · 49 participants | Very low Downgraded: risk of bias, imprecision |
Early and late (day 1 to 28 after birth) higher versus lower sodium intake for preterm infants
Population: preterm or low birth weight infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality (latest time reported up to hospital discharge) Early and late (day 1 to 28 after birth) higher vs lower sodium intake | no estimate extracted | 0 studies · 0 participants | Ungraded |
Neurodevelopmental disability Early and late (day 1 to 28 after birth) higher vs lower sodium intake | no estimate extracted | 0 studies · 0 participants | Ungraded |
Hyponatraemia (< 130 mmol/L) Early and late (day 1 to 28 after birth) higher vs lower sodium intake | no estimate extracted | 0 studies · 0 participants | Ungraded |
Hypernatraemia (≥ 150 mmol/L) Early and late (day 1 to 28 after birth) higher vs lower sodium intake | RR 2.5 [0.63, 10] | 1 study · 20 participants | Very low Downgraded: risk of bias, imprecision |
Postnatal growth failure (weight < 10th percentile) Early and late (day 1 to 28 after birth) higher vs lower sodium intake | no estimate extracted | 0 studies · 0 participants | Ungraded |
Necrotising enterocolitis Early and late (day 1 to 28 after birth) higher vs lower sodium intake | no estimate extracted | 0 studies · 0 participants | Ungraded |
Chronic lung disease Early and late (day 1 to 28 after birth) higher vs lower sodium intake | no estimate extracted | 0 studies · 0 participants | Ungraded |