Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

633 questions · 668 findings · 122 reviews · Headline outcomes only

No studies found 144 · 21.6%GRADE not reported 27 · 4%Very low 154 · 23.1%Low 194 · 29%Moderate 119 · 17.8%High 30 · 4.5%

Quinolone vs macrolides

Quality of life Drug resistance/microbial sensitivity Serious adverse events Lung function Hospitalisations Adverse events/side effects Number of participants colonised with P aeruginosa · patients with chronic obstructive pulmonary disease

The review found no eligible studies for this question.

1 finding from 1 review

PTFE vs Dacron

Primary patency ( · people with peripheral vascular disease requiring above‐knee femoro‐popliteal bypass surgery

PTFE showed no clear difference in primary patency (24 months) compared with dacron (low certainty).

2 findings from 1 review

PTFE vs Dacron

Secondary patency (24 months) · people with peripheral vascular disease requiring above‐knee femoro‐popliteal bypass surgery

PTFE may leads to higher secondary patency (24 months) compared with dacron (low certainty).

1 finding from 1 review

PTFE vs Dacron

Limb salvage · people with peripheral vascular disease requiring above‐knee femoro‐popliteal bypass surgery

PTFE showed no clear difference in limb salvage (24 months) compared with dacron (low certainty).

1 finding from 1 review

Endovascular coiling vs neurosurgical clipping

Death or dependence · people with subarachnoid haemorrhage from a ruptured intracranial aneurysm

Endovascular coiling probably leads to lower poor outcome: death or dependence in daily activities (12 months) compared with neurosurgical clipping (moderate certainty).

2 findings from 1 review

Endovascular coiling vs neurosurgical clipping

Death from any cause (12 months) · people with subarachnoid haemorrhage from a ruptured intracranial aneurysm

Endovascular coiling showed no clear difference in death from any cause (12 months) compared with neurosurgical clipping (moderate certainty).

1 finding from 1 review

Endovascular coiling vs neurosurgical clipping

Delayed cerebral ischaemia · people with subarachnoid haemorrhage from a ruptured intracranial aneurysm

Endovascular coiling probably leads to lower delayed cerebral ischaemia (2–3 months) compared with neurosurgical clipping (moderate certainty).

1 finding from 1 review

Endovascular coiling vs neurosurgical clipping

Rebleeding · people with subarachnoid haemorrhage from a ruptured intracranial aneurysm

Endovascular coiling leads to higher rebleeding postprocedure up to 1 year compared with neurosurgical clipping (high certainty).

2 findings from 1 review

Endovascular coiling vs neurosurgical clipping

Complications from the intervention · people with subarachnoid haemorrhage from a ruptured intracranial aneurysm

Endovascular coiling showed no clear difference in complications from the intervention compared with neurosurgical clipping (low certainty).

1 finding from 1 review

Larger atraumatic needles vs atraumatic needles

Onset of PDPH · patients undergoing lumbar punctures with atraumatic needles (Whitacre, Atraucan, Sprotte, Cappe‐Deutsh, Pajunk, Gertie Marx, Durasafe,…

Larger atraumatic needles may leads to lower onset of PDPH compared with smaller atraumatic needles (low certainty).

1 finding from 1 review

Larger atraumatic needles vs atraumatic needles

Paraesthesia · patients undergoing lumbar punctures with atraumatic needles (Whitacre, Atraucan, Sprotte, Cappe‐Deutsh, Pajunk, Gertie Marx, Durasafe,…

Larger atraumatic needles probably leads to lower adverse events: paraesthesia compared with smaller atraumatic needles (moderate certainty).

1 finding from 1 review

Larger atraumatic needles vs atraumatic needles

Adverse events: backache · patients undergoing lumbar punctures with atraumatic needles (Whitacre, Atraucan, Sprotte, Cappe‐Deutsh, Pajunk, Gertie Marx, Durasafe,…

Larger atraumatic needles probably leads to lower adverse events: backache compared with smaller atraumatic needles (moderate certainty).

1 finding from 1 review

Larger atraumatic needles vs atraumatic needles

Severe PDPH · patients undergoing lumbar punctures with atraumatic needles (Whitacre, Atraucan, Sprotte, Cappe‐Deutsh, Pajunk, Gertie Marx, Durasafe,…

Larger atraumatic needles showed no clear difference in severe PDPH compared with smaller atraumatic needles (low certainty).

1 finding from 1 review

Larger atraumatic needles vs atraumatic needles

Headache · patients undergoing lumbar punctures with atraumatic needles (Whitacre, Atraucan, Sprotte, Cappe‐Deutsh, Pajunk, Gertie Marx, Durasafe,…

Larger atraumatic needles probably leads to lower any headache compared with smaller atraumatic needles (moderate certainty).

1 finding from 1 review