Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,368 questions · 1,413 findings · 89 reviews · Common Mental Disorders

No studies found 232 · 16.4%GRADE not reported 82 · 5.8%Very low 395 · 28%Low 331 · 23.4%Moderate 341 · 24.1%High 32 · 2.3%

Topiramate as add‐on therapy vs alternative drug

Remission with topiramate. Number of participants presenting with a rating scale score within the normal range at the endpoint in depressive episodes (8 weeks) · adults with acute affective episodes in bipolar disorder

It is very uncertain whether topiramate as add‐on therapy changes remission with topiramate. Number of participants presenting with a… compared with alternative drug (very low certainty).

1 finding from 1 review

Topiramate vs placebo

Remission · adults with acute affective episodes in bipolar disorder

The review found no eligible studies for this question.

2 findings from 1 review

Psychological therapies vs SSRI

Short‐term improvement Scale used (range; lower is better): panic frequency Clinical Global Impression (1 to 7) Agoraphobic Cognitive Questionnaire (1 to 70) Fear Questionnaire Agoraphobia Subscale (0 to 14) · adults with panic disorder
1 finding from 1 review

DCS and cognitive and behavioural therapies vs placebo and cognitive and behavioural therapies

Co‐morbid depression · children and adolescents with anxiety disorders

It is very uncertain whether DCS and cognitive and behavioural therapies changes co‐morbid symptoms of depression As assessed by CDI5 (scale from 0… compared with placebo and cognitive and behavioural therapies (very low certainty).

1 finding from 1 review

DCS and cognitive and behavioural therapies vs placebo and cognitive and behavioural therapies

Co‐morbid depression · adults with anxiety disorders

DCS and cognitive and behavioural therapies showed no clear difference in co‐morbid symptoms of depression As assessed by BDI‐II7 (scale from:… compared with placebo and cognitive and behavioural therapies (moderate certainty).

1 finding from 1 review

Psychological therapy vs Waitlist/Usual Care

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · people with somatoform disorders and medically unexplained physical symptoms

Psychological therapy may leads to higher treatment response at end of treatment CGI‐improvement/Global… compared with usual care or waiting list (low certainty).

1 finding from 1 review

CBT vs control

Depression symptoms ‐ comparisons at 0 to 3 months post‐treatment Lower scores indicate reduced depression symptoms, and thus positive outcomes1 · patients with pathological and problem gambling
1 finding from 1 review