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Evidence found and GRADE certainty

4,315 questions · 23,557 findings · 2,311 reviews

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No studies found 4,183 · 17.8%GRADE not reported 3,930 · 16.7%Very low 5,371 · 22.8%Low 5,787 · 24.6%Moderate 3,320 · 14.1%High 966 · 4.1%

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Summary of findings: endovenous ablation and compression vs compression alone

Ulcer healing time (measured as days from randomisation and followed‐up to 1 year) · people with venous leg ulcers

Summary of findings: endovenous ablation and compression leads to higher ulcer healing time (measured as days from randomisation and… compared with compression alone (high certainty).

1 finding from 1 review

Summary of findings: endovenous ablation and compression vs compression alone

The proportion of pressure ulcers healed · people with venous leg ulcers

Summary of findings: endovenous ablation and compression showed no clear difference in proportion of ulcers healed at 90 days (90 days compared with compression alone (moderate certainty).

2 findings from 1 review

Country-level edentulism prevalence (Global Burden of Disease) vs Low vs high edentulism prevalence

Oral health-related quality of life · people aged 60 years and older living in the community

OHRQoL did not differ significantly by country-level edentulism prevalence; no pooled estimate was reported in the text (ungraded).

1 finding from 1 review

Chlorhexidine rinse (0.12% and 0.2%, pre- and post-extraction) vs placebo or no treatment

Adverse events · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)
1 finding from 1 review
  • Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
    Follow-up: median 7 days
    3 trials reported no adverse events. 1 study reported adverse events (alterations in taste, bad taste, staining) in 24/62 in chlorhexidine group versus 0/40 in placebo group, Peto OR = 8.42 (95% CI 3.31 to 21.39). A…
    6 studies
    GRADE not reported

Country-level dental caries prevalence (Global Burden of Disease) vs Low vs high dental caries prevalence

Oral health-related quality of life · people aged 60 years and older living in the community

Lower country-level dental caries prevalence was associated with better OHRQoL (low-prevalence pooled mean 81.5, 95% CI 76.5 to 86.6, higher than high-prevalence countries); statistically significant (ungraded).

1 finding from 1 review

Genome-wide common variants (additive dosage; present-study GWAS) vs Genome-wide significance threshold (P<5E-8)

Dental caries - genome-wide-significant loci · Japanese adults (present-study cohort: 30,859 dental caries cases / 14,666 controls)

The present Japanese GWAS found no genome-wide-significant loci for dental caries (top suggestive rs140784657); ungraded.

1 finding from 1 review
  • Genome-wide association meta-analysis identifies two novel loci associated with dental caries. 2024 All outcomes
    Lifelong (germline genotype) · Population-based genetic association study (Japanese direct-to-consumer genetic testing cohort) · Present-study GWAS (Japanese)
    In the present Japanese GWAS, no loci reached genome-wide significance (P<5E-8) for dental caries; several loci reached the suggestive level (P<1E-5). Top-associated variant rs140784657 (intergenic). All 47 lead…
    1 study · 45525 participants
    GRADE not reported

Prefabricated zirconia crowns (e.g., NuSmile, Zirkiz, Kinder Krown) vs Other crowns/restorations (stainless steel crowns, pre-veneered SSC, resin composite strip crowns, glass-fiber composite crowns)

Recurrent caries (crowns free of recurrent caries) · Children with primary (deciduous) teeth requiring full-coverage crown restoration

Recurrent caries did not differ between zirconia crowns and other restorations at 6 months (RR 1.00, 95% CI 0.97 to 1.03; 2 studies; not GRADE-rated).

2 findings from 1 review

Prefabricated zirconia crowns (e.g., NuSmile, Zirkiz, Kinder Krown) vs Other crowns/restorations (stainless steel crowns, pre-veneered SSC, resin composite strip crowns, glass-fiber composite crowns)

Crown retention · Children with primary (deciduous) teeth requiring full-coverage crown restoration

Zirconia crowns showed no significant difference in crown retention versus other restorations at 6 months (RR 1.02, 95% CI 0.94 to 1.11; 3 studies; not GRADE-rated).

1 finding from 1 review

Country-level periodontal disease prevalence (Global Burden of Disease) vs Low vs high periodontal disease prevalence

Oral health-related quality of life · people aged 60 years and older living in the community

OHRQoL did not differ significantly by country-level periodontal disease prevalence; no pooled estimate was reported in the text (ungraded).

1 finding from 1 review

Summary of findings table ‐ Oral classical immunosuppressants (betamethasone) vs oral classical immunosuppressants (azathioprine, methotrexate, prednisolone)

Short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of · adults with alopecia areata

Summary of findings table ‐ Oral classical immunosuppressants… showed no clear difference in short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of compared with oral classical immunosuppressants (azathioprine, methotrexate,… (low certainty).

1 finding from 1 review