Findings

What do systematic reviews say?

4,587 questions · 5,761 findings · 495 reviews

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No studies found 1,011 · 17.5%GRADE not reported 1,797 · 31.2%Very low 1,100 · 19.1%Low 1,052 · 18.3%Moderate 649 · 11.3%High 152 · 2.6%

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Presence of oral Candida albicans vs Absence of oral Candida albicans

Early childhood caries (ECC) · Children aged ≤6 years (early childhood)

RETRACTED. Among studies before 2017, oral C. albicans presence was associated with higher odds of ECC (OR 4.89, 95% CI 2.79-8.58); ungraded subgroup from a retracted review.

16 findings from 1 review

RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomes
Exposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Time period: before 2017
OR 4.89 [2.79, 8.58]
10 studies
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomes
Exposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Sample collection: dental plaque
OR 4.08 [2.65, 6.27]
13 studies
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomes
Exposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Region: Europe
OR 10.13 [6.01, 17.09]
5 studies · 635 participants
GRADE not reported

Show 13 more findings

RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomes
Exposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Study quality (NOS): good
OR 5.32 [2.89, 9.80]
7 studies
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomes
Exposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Sample collection: saliva
OR 4.70 [2.44, 9.09]
7 studies
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomes
Exposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Overall (all 22 studies, random-effects)
OR 4.42 [3.14, 6.24]
22 studies · 3301 participants
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomes
Exposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Sample size: >=100 (Table 6; abstract text erroneously states '>=1000')
OR 4.65 [2.57, 8.42]
6 studies
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomes
Exposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Sample collection: oral swab
OR 9.55 [2.17, 42.01]
2 studies
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomes
Exposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Study design: case-control
OR 5.30 [1.72, 16.31]
2 studies · 708 participants
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomes
Exposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Region: Asia
OR 3.62 [2.53, 5.20]
12 studies · 2347 participants
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomes
Exposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Sample size: <100 (Table 6; abstract text erroneously states '<1000')
OR 4.35 [2.75, 6.89]
16 studies
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomes
Exposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Time period: 2018 and later
OR 4.17 [2.62, 6.64]
12 studies
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomes
Exposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Study design: cross-sectional
OR 4.30 [2.92, 6.33]
20 studies · 2593 participants
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomes
Exposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Study quality (NOS): moderate
OR 3.84 [2.24, 6.57]
11 studies
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomes
Exposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Region: America/Canada/Brazil/Chile
OR 3.98 [1.14, 13.87]
5 studies · 319 participants
GRADE not reported
RETRACTED: Investigating the association between Candida albicans and early childhood dental caries: A comprehensive… 2024 All outcomes
Exposure and outcome assessed concurrently (observational); children aged ≤6 years · Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings · Study quality (NOS): low
OR 5.14 [2.12, 12.48]
4 studies
GRADE not reported

38% SDF plus oral health education vs oral health instruction plus water

new root-surface carious lesions or restorations · community-dwelling older adults with root caries

SDF plus oral health education had a 33% preventative fraction at 24 months; no pooled estimate or GRADE rating was reported.

1 finding from 1 review

A systematic review on the effect of silver diamine fluoride for management of dental caries in permanent teeth. 2023 All outcomes
24 months · Hong Kong
Preventative fraction (%) 33
1 study · 266 participants
GRADE not reported

Oral ivermectin 200 μg/kg (1 dose) vs oral ivermectin 200 μg/kg (2 doses)

Complete clearance · people with scabies, over 5 years of ageLocation: India

Oral ivermectin 200 μg/kg (1 dose) showed no clear difference in complete clearance ‐ week 4 compared with oral ivermectin 200 μg/kg (2 doses) (high certainty).

1 finding from 1 review

Ivermectin and permethrin for treating scabies 2018 · Cochrane Headline outcomes only
RR 0.97 [0.83, 1.14]
1 study · 80 participants
High

Oral ivermectin 200 μg/kg (1 dose) vs oral ivermectin 200 μg/kg (2 doses)

1Sharma 2011. · people with scabies, over 5 years of ageLocation: India

1 finding from 1 review

Ivermectin and permethrin for treating scabies 2018 · Cochrane Headline outcomes only
no estimate extracted
1 participants
GRADE not reported

Statin plus oral contraceptive pill vs oral contraceptive pill (OCP)

Resumption of menstrual regularity · women with polycystic ovary syndrome not actively trying to conceive

1 finding from 1 review

Statins for women with polycystic ovary syndrome not actively trying to conceive 2023 · Cochrane Headline outcomes only
no estimate extracted
2006 participants
GRADE not reported

Statin plus oral contraceptive pill vs oral contraceptive pill (OCP)

Resumption of spontaneous ovulation · women with polycystic ovary syndrome not actively trying to conceive

1 finding from 1 review

Statins for women with polycystic ovary syndrome not actively trying to conceive 2023 · Cochrane Headline outcomes only
no estimate extracted
2006 participants
GRADE not reported

Statin plus oral contraceptive pill vs oral contraceptive pill (OCP)

Clinician's assessment of improvement of hirsutism Ferriman‐Gallwey score Scale from: 0 to 36 · women with polycystic ovary syndrome not actively trying to conceive

1 finding from 1 review

Statins for women with polycystic ovary syndrome not actively trying to conceive 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 48 participants
Very low

Statin plus oral contraceptive pill vs oral contraceptive pill (OCP)

Improvement in acne severity · women with polycystic ovary syndrome not actively trying to conceive

1 finding from 1 review

Statins for women with polycystic ovary syndrome not actively trying to conceive 2023 · Cochrane Headline outcomes only
no estimate extracted
2006 participants
GRADE not reported

Statin plus oral contraceptive pill vs oral contraceptive pill (OCP)

Improvement in testosterone level (nmol/L) after 6 months' treatment · women with polycystic ovary syndrome not actively trying to conceive

1 finding from 1 review

Statins for women with polycystic ovary syndrome not actively trying to conceive 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 48 participants
Very low

Statin plus oral contraceptive pill vs oral contraceptive pill (OCP)

Adverse effects · women with polycystic ovary syndrome not actively trying to conceive

1 finding from 1 review

Statins for women with polycystic ovary syndrome not actively trying to conceive 2023 · Cochrane Headline outcomes only
no estimate extracted
2006 participants
GRADE not reported

38% SDF plus oral health education vs oral health instruction plus tonic water

new root-surface carious lesions or restorations · community-dwelling older adults with root caries

SDF had a 62% preventative fraction; no pooled estimate or GRADE rating was reported.

1 finding from 1 review

A systematic review on the effect of silver diamine fluoride for management of dental caries in permanent teeth. 2023 All outcomes
30 months · Hong Kong
Preventative fraction (%) 62
1 study · 323 participants
GRADE not reported

Mycophenolate sodium + oral steroids vs oral steroids alone

Complete remission · minimal change disease in adults with nephrotic syndrome

Mycophenolate sodium + oral steroids showed no clear difference in complete remission Time frame: 4 weeks compared with oral steroids alone (moderate certainty).

2 findings from 1 review

Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
RR 1.12 [0.84, 1.5]
1 study · 114 participants
Moderate
Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
RR 1.08 [0.84, 1.38]
2 studies · 134 participants
Moderate

Mycophenolate sodium + oral steroids vs oral steroids alone

Complete or partial remission · minimal change disease in adults with nephrotic syndrome

Mycophenolate sodium + oral steroids showed no clear difference in complete or partial remission Time frame: 24 weeks to end of treatment compared with oral steroids alone (moderate certainty).

1 finding from 1 review

Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
RR 0.92 [0.75, 1.12]
2 studies · 134 participants
Moderate

Mycophenolate sodium + oral steroids vs oral steroids alone

Relapse · minimal change disease in adults with nephrotic syndrome

Mycophenolate sodium + oral steroids showed no clear difference in relapse Time frame: 24 weeks compared with oral steroids alone (low certainty).

1 finding from 1 review

Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
RR 0.43 [0.08, 2.25]
2 studies · 80 participants
Low

Mycophenolate sodium + oral steroids vs oral steroids alone

Adverse events: death · minimal change disease in adults with nephrotic syndrome

Mycophenolate sodium + oral steroids showed no clear difference in adverse events: death compared with oral steroids alone (low certainty).

1 finding from 1 review

Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
RR 0.67 [0.12, 3.84]
1 study · 116 participants
Low

Mycophenolate sodium + oral steroids vs oral steroids alone

Acute kidney injury · minimal change disease in adults with nephrotic syndrome

Mycophenolate sodium + oral steroids showed no clear difference in adverse events: acute kidney injury compared with oral steroids alone (low certainty).

1 finding from 1 review

Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
RR 0.5 [0.05, 5.36]
1 study · 116 participants
Low

Mycophenolate sodium + oral steroids vs oral steroids alone

Adverse events: new‐onset glucose intolerance · minimal change disease in adults with nephrotic syndrome

Mycophenolate sodium + oral steroids showed no clear difference in adverse events: new‐onset glucose intolerance compared with oral steroids alone (low certainty).

1 finding from 1 review

Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
RR 0.2 [0.01, 4.08]
2 studies · 136 participants
Low

Extra-oral pulp extirpation at day 0 vs Intra-oral pulp extirpation at day 7

Adverse effects · People with avulsed and replanted permanent (front) teeth

1 finding from 1 review

Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted 2019 · Cochrane All outcomes
Giannetti 2006 did not report this outcome; following email correspondence, authors reported no adverse effects were seen (uncertain whether formally assessed).
1 study
GRADE not reported

Dextrose gel vs oral (swallowed) glucose

Resolution of symptoms · adult patients with insulin‐dependent diabetes

It is very uncertain whether oral + buccal glucose (dextrose gel) changes resolution of symptoms within 20 minutes compared with oral (swallowed) glucose (very low certainty).

1 finding from 1 review

First aid glucose administration routes for symptomatic hypoglycaemia 2019 · Cochrane Headline outcomes only
RR 0.36 [0.12, 1.14]
1 study · 18 participants
Very low

Dextrose gel vs oral (swallowed) glucose

Time to symptom resolution · adult patients with insulin‐dependent diabetes

The review found no eligible studies for this question.

1 finding from 1 review

First aid glucose administration routes for symptomatic hypoglycaemia 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found