Cochrane · systematic review · CD012994
Ivermectin and permethrin for treating scabies
Rosumeck, S, Nast, A, Dressler, C · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
23
current version
GRADE rated
22
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 4.3%Very low 3 · 13%Low 7 · 30.4%Moderate 9 · 39.1%High 3 · 13%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Oral ivermectin 200 μg/kg (1 to 3 doses) compared to topical permethrin 5% cream (1 to 3 applications)
Population: people with scabies, 2 to 80 years of ageLocation: India, Pakistan
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete clearance ‐ week 1 Oral ivermectin 200 μg/kg (1 to 3 doses) vs topical permethrin 5% cream (1 to 3 applications) | RR 0.65 [0.54, 0.78] | 6 studies · 613 participants | Low Downgraded: risk of bias, imprecision |
Complete clearance ‐ week 2 Oral ivermectin 200 μg/kg (1 to 3 doses) vs topical permethrin 5% cream (1 to 3 applications) | RR 0.91 [0.76, 1.08] | 5 studies · 459 participants | Low Downgraded: risk of bias, inconsistency |
Complete clearance ‐ week 4 ‐ IVER 1 dose versus PER 1 application Oral ivermectin 200 μg/kg (1 to 3 doses) vs topical permethrin 5% cream (1 to 3 applications) | RR 1 [0.86, 1.16] | 1 study · 80 participants | High |
Complete clearance ‐ week 4 ‐ IVER 1 to 3 doses versus PER 1 to 3 applications Oral ivermectin 200 μg/kg (1 to 3 doses) vs topical permethrin 5% cream (1 to 3 applications) | RR 0.92 [0.82, 1.03] | 5 studies · 581 participants | Low Downgraded: risk of bias, inconsistency |
Complete clearance ‐ week 4 ‐ IVER 2 doses versus PER 1 application Oral ivermectin 200 μg/kg (1 to 3 doses) vs topical permethrin 5% cream (1 to 3 applications) | RR 0.97 [0.83, 1.14] | 1 study · 80 participants | High |
Number of participants with ≥ 1 AE ‐ week 2 Oral ivermectin 200 μg/kg (1 to 3 doses) vs topical permethrin 5% cream (1 to 3 applications) | no estimate extracted | 1 study · 55 participants | Moderate Downgraded: risk of bias |
Number of participants with ≥ 1 AE ‐ week 4 Oral ivermectin 200 μg/kg (1 to 3 doses) vs topical permethrin 5% cream (1 to 3 applications) | RR 1.3 [0.35, 4.83] | 4 studies · 502 participants | Low Downgraded: risk of bias, imprecision |
Withdrawal due to AE ‐ week 4 Oral ivermectin 200 μg/kg (1 to 3 doses) vs topical permethrin 5% cream (1 to 3 applications) | no estimate extracted | 3 studies · 305 participants | Moderate Downgraded: risk of bias |
Oral ivermectin 200 μg/kg (1 to 2 doses) compared to topical permethrin 5% lotion (1 to 5 applications)
Population: people with scabies, 5 to 60 years of ageLocation: Egypt, Pakistan
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete clearance ‐ week 1 ‐ IVER 1 dose versus PER 1 application Oral ivermectin 200 μg/kg (1 to 2 doses) vs topical permethrin 5% lotion (1 to 5 applications) | RR 0.93 [0.74, 1.17] | 1 study · 120 participants | Moderate Downgraded: risk of bias |
Complete clearance ‐ week 1 ‐ IVER 1 dose versus PER on 5 consecutive nights Oral ivermectin 200 μg/kg (1 to 2 doses) vs topical permethrin 5% lotion (1 to 5 applications) | RR 0.7 [0.47, 1.03] | 1 study · 107 participants | Low Downgraded: risk of bias, imprecision |
Complete clearance ‐ week 2 ‐ IVER 1 dose versus PER 1 application Oral ivermectin 200 μg/kg (1 to 2 doses) vs topical permethrin 5% lotion (1 to 5 applications) | RR 1 [0.78, 1.29] | 1 study · 120 participants | Low Downgraded: risk of bias, imprecision |
Complete clearance ‐ week 2 ‐ IVER 2 doses versus PER on 5 consecutive nights Oral ivermectin 200 μg/kg (1 to 2 doses) vs topical permethrin 5% lotion (1 to 5 applications) | RR 0.97 [0.81, 1.17] | 1 study · 107 participants | Moderate Downgraded: risk of bias |
Number of participants with ≥ 1 AE ‐ week 2 ‐ IVER 2 doses versus PER on 5 consecutive nights Oral ivermectin 200 μg/kg (1 to 2 doses) vs topical permethrin 5% lotion (1 to 5 applications) | RR 5 [0.25, 101.58] | 1 study · 100 participants | Very low Downgraded: risk of bias, imprecision |
Withdrawal due to AE ‐ week 2 ‐ IVER 1 dose versus PER 1 application Oral ivermectin 200 μg/kg (1 to 2 doses) vs topical permethrin 5% lotion (1 to 5 applications) | no estimate extracted | 1 study · 120 participants | Moderate Downgraded: risk of bias |
Oral ivermectin 200 μg/kg (1 to 3 doses) compared to topical ivermectin 1% lotion/solution (1 to 3 applications)
Population: people with scabies, 5 to 80 years of ageLocation: Egypt, India
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete clearance ‐ week 1 Oral ivermectin 200 μg/kg (1 to 3 doses) vs topical ivermectin 1% lotion/solution (1 to 3 applications) | RR 0.84 [0.65, 1.08] | 1 study · 62 participants | Low Downgraded: risk of bias, imprecision |
Complete clearance ‐ week 2 Oral ivermectin 200 μg/kg (1 to 3 doses) vs topical ivermectin 1% lotion/solution (1 to 3 applications) | RR 1 [0.94, 1.06] | 1 study · 62 participants | Moderate Downgraded: risk of bias |
Complete clearance ‐ week 4 Oral ivermectin 200 μg/kg (1 to 3 doses) vs topical ivermectin 1% lotion/solution (1 to 3 applications) | RR 0.99 [0.95, 1.03] | 2 studies · 272 participants | Moderate Downgraded: risk of bias |
Number of participants with ≥ 1 AE ‐ week 4 Oral ivermectin 200 μg/kg (1 to 3 doses) vs topical ivermectin 1% lotion/solution (1 to 3 applications) | RR 5.05 [0.25, 103.87] | 1 study · 201 participants | Very low Downgraded: risk of bias, imprecision |
Withdrawal due to AE ‐ week 4 Oral ivermectin 200 μg/kg (1 to 3 doses) vs topical ivermectin 1% lotion/solution (1 to 3 applications) | no estimate extracted | 1 study · 62 participants | Moderate Downgraded: risk of bias |
Topical ivermectin 1% lotion (1 to 3 applications) compared to topical permethrin 5% cream (1 to 3 applications)
Population: people with scabies, 5 to 80 years of ageLocation: India
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete clearance ‐ week 4 Topical ivermectin 1% lotion (1 to 3 applications) vs topical permethrin 5% cream (1 to 3 applications) | RR 1.02 [0.96, 1.08] | 1 study · 210 participants | Moderate Downgraded: risk of bias |
Number of participants with ≥ 1 AE ‐ week 4 Topical ivermectin 1% lotion (1 to 3 applications) vs topical permethrin 5% cream (1 to 3 applications) | RR 0.33 [0.01, 7.93] | 1 study · 200 participants | Very low Downgraded: risk of bias, imprecision |
Oral ivermectin 200 μg/kg (1 dose) compared to oral ivermectin 200 μg/kg (2 doses)
Population: people with scabies, over 5 years of ageLocation: India
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete clearance ‐ week 4 Oral ivermectin 200 μg/kg (1 dose) vs oral ivermectin 200 μg/kg (2 doses) | RR 0.97 [0.83, 1.14] | 1 study · 80 participants | High |
1Sharma 2011. Oral ivermectin 200 μg/kg (1 dose) vs oral ivermectin 200 μg/kg (2 doses) | no estimate extracted | 1 participants | Ungraded |